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NIPP AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of NIPP antibodies. Select NIPP antibodies from several monoclonal and/or polyclonal NIPP antibodies listed below. View detailed NIPP antibody specifications by linking to the specific product blocks. Select appropriate NIPP antibodies for your research by isotype, epitope, applications and species reactivity. NIPP gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of NIPP Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
NIPP siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
NIPP1 (nuclear inhibitor of protein phosphatase 1) is a putative transcription regulator that may be involved in pre-mRNA splicing and cell proliferation. NIPP1 contains a nuclear signaling region named FHA (forkhead-associated) domain. The FHA domain has been associated with protein kinases and transcription factors. The NIPP1 locus encodes for three different isoforms termed α, β and γ due to alternative splicing events. The isoforms exhibit RNA binding activity and also act as phophatase inhibitors. The γ isoform is believed to be a magnesium-dependent endoribonuclease that is responsible for cleaving RNA strands. It is mainly found in B cells and T lymphocytes. The α and β isoforms are localized in the brain and kidney. Inactivation of NIPP1 is accom-plished by the phosphorylation of Ser 199 or Ser 204. NIPP1 interacts with proteins CDc5L, SAP 155, MELK and EED. |
