Neuregulin Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of Neuregulin antibodies. Select Neuregulin antibodies from several monoclonal and/or polyclonal Neuregulin antibodies listed below. View detailed Neuregulin antibody specifications by linking to the specific product blocks. Select appropriate Neuregulin antibodies for your research by isotype, epitope, applications and species reactivity. Neuregulin gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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Also see additional Neuregulin Antibodies including, Neuregulin-1, Neuregulin-1 alpha, Neuregulin-1 beta 1, Neuregulin-1 beta 2, Neuregulin-1 beta 3, Neuregulin-1 GGF2, Neuregulin-1 SMDF... See More, Neuregulin-2, Neuregulin-3, Neuregulin-4

The ErbB/HER family of receptor tyrosine kinases consists of four receptors that bind a large number of growth factor ligands sharing an epidermal growth factor-(EGF)-like motif. The neuregulins (NRGs) are a diverse family of proteins that arise by alternative splicing from a single gene. These proteins play an important role in controlling the growth and differentiation of glial, epithelial, and muscle cells. Whereas ErbB-1 binds seven different ligands whose prototype is EGF, the four families of neuregulins activate ErbB-3 and/or ErbB-4. Neuregulin-1 (also known as heregulin) has diverse functions in neural development, and one of them is to up-regulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions. Neuregulin-2 exhibits a distinct expression pattern in adult brain and developing heart. Neuregulin-3 is expressed in cell lines derived from breast cancer and is a potential regulator of normal and malignant breast epithelial cells. Neuregulin-4 is detected in the adult pancreas and weakly in muscle.