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Welcome to Santa Cruz Biotechnology!
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MSR AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of MSR antibodies. Select MSR antibodies from several monoclonal and/or polyclonal MSR antibodies listed below. View detailed MSR antibody specifications by linking to the specific product blocks. Select appropriate MSR antibodies for your research by isotype, epitope, applications and species reactivity. MSR gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of MSR Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
MSR siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
The methylation of homocysteine to methionine (an essential amino acid in humans) is catalyzed by a cobalamin-dependent enzyme, methionine synthase (MS), for which MSR (Methionine Synthase Reductase) acts as a chaperone protein. Over time, the cob(I)alamin cofactor of MS becomes oxidized to cob(II)alamin, thus inactivating MS. Regeneration of active MS requires reductive methylation catalyzed by MSR in which SAM is used as a methyl donor. MSR maintains MS activity at a 1:1 stoichiometric ratio. In the presence of MSR and NADPH, holoenzyme formation from apoMS and methylcobalamin is significantly heightened due to stabilization of apoMS in the presence of MSR. MSR is also able to decrease aquacobalamin to cob(II)alamin in the presence of NADPH, which stimulates conversion of apoMS and aquacobalamin to holoMS. |
