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MKLP-1 Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of MKLP-1 antibodies. Select MKLP-1 antibodies from several monoclonal and/or polyclonal MKLP-1 antibodies listed below. View detailed MKLP-1 antibody specifications by linking to the specific product blocks. Select appropriate MKLP-1 antibodies for your research by isotype, epitope, applications and species reactivity. MKLP-1 gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle and CRISPR/Cas9 Knockout Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids for gene activation.

Introducing HOVERcruz™,

a unique system for rapid identification of MKLP-1 Antibodies. Hover over product names in the table to see representative data for each product.

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See chemical MKLP-1 Inhibitors for functional analysis of cellular responses to MKLP-1.

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
MKLP-1 (C-12)sc-390113mouse IgG11-110 (h)WB, IP, IF, ELISAhuman
MKLP-1 (N-19)sc-867rabbit IgGN-terminal (h)WB, IP, IF, IHC(P), ELISAh > m, r14
MKLP-1 (Q-16)sc-33336goat IgGC-terminal (h)WB, IF, ELISAm, r, h, e, c, b, p, a
MKLP-1 (H-110)sc-22793rabbit IgG1-110 (h)WB, IP, IF, IHC(P), ELISAm, r, h, b3
MKLP-1 (24)sc-136473mouse IgG2aN/AWBm, r, h1
MKLP-1 (D-17)sc-33335goat IgGinternal (h)WB, IP, IF, ELISAh, e, c, b, p > r

MKLP-1 CRISPR Knockout and HDR Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
MKLP-1 CRISPR/Cas9 KO Plasmid (h)sc-400696humanGene KnockoutNEWNot Yet Rated
MKLP-1 HDR Plasmid (h)sc-400696-HDRhumanHomology Directed RepairNEWNot Yet Rated
MKLP-1 CRISPR/Cas9 KO Plasmid (m)sc-428080mouseGene KnockoutNEWNot Yet Rated
MKLP-1 HDR Plasmid (m)sc-428080-HDRmouseHomology Directed RepairNEWNot Yet Rated

MKLP-1 CRISPR Activation Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
MKLP-1 CRISPR Activation Plasmid (h)sc-400696-ACThumanGene ActivationNEWNot Yet Rated
MKLP-1 CRISPR Activation Plasmid (m)sc-428080-ACTmouseGene ActivationNEWNot Yet Rated

MKLP-1 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
MKLP-1 siRNA (h)sc-35936humanGene Silencing
MKLP-1 shRNA Plasmid (h)sc-35936-SHhumanGene Silencing
MKLP-1 shRNA (h) Lentiviral Particlessc-35936-VhumanGene Silencing
MKLP-1 siRNA (m)sc-37626mouseGene SilencingNot Yet Rated
MKLP-1 shRNA Plasmid (m)sc-37626-SHmouseGene SilencingNot Yet Rated
MKLP-1 shRNA (m) Lentiviral Particlessc-37626-VmouseGene SilencingNot Yet Rated

The monoclonal antibody CHO1 detects a spindle antigen required for mitotic progression. Screening a HeLa cell cDNA expression library with this antibody has been shown to yield a cDNA predicted to encode a protein significantly related within its amino terminal half to the motor ends of members of the kinesin superfamily. Since this similarity does not extend further, it has been suggested that the CHO1 antigen, now designated MKLP-1 (mitotic kinesin-like protein-1), represents a novel kinesin. Sequence analysis has also been shown to predict that MKLP-1 possesses features typical of nuclear proteins. Immunocytological studies have demonstrated that MKLP-1 moves from the nucleus early in mitosis and then to the midbody after cytokinesis. MKLP-1 has been shown to bundle antiparallel microtubules in vitro and to move them at rates comparable to spindle elongation in vivo. A hamster homolog of MKLP-1, designated CHO1 antigen, has also been isolated. Although apparently functionally equivalent with respect to microtubule bundling activity, there are significant differences between the human and hamster proteins at their C-termini, possibly due to alternative splicing or the presence of more than one MKLP-1 locus.