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MKLP-1 Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of MKLP-1 antibodies. Select MKLP-1 antibodies from several monoclonal and/or polyclonal MKLP-1 antibodies listed below. View detailed MKLP-1 antibody specifications by linking to the specific product blocks. Select appropriate MKLP-1 antibodies for your research by isotype, epitope, applications and species reactivity. MKLP-1 gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle and CRISPR/Cas9 Knockout Plasmid formats are also available.

Introducing HOVERcruz™,

a unique system for rapid identification of MKLP-1 Antibodies. Hover over product names in the table to see representative data for each product.

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Our live chat system is available to answer your product and ordering questions.

See chemical MKLP-1 Inhibitors for functional analysis of cellular responses to MKLP-1.

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
MKLP-1 (C-12)sc-390113mouse IgG11-110 (h)WB, IP, IF, ELISAhumanNEW
MKLP-1 (N-19)sc-867rabbit IgGN-terminal (h)WB, IP, IF, IHC(P), ELISAh > m, r14
MKLP-1 (Q-16)sc-33336goat IgGC-terminal (h)WB, IF, ELISAm, r, h, e, c, b, p, a
MKLP-1 (H-110)sc-22793rabbit IgG1-110 (h)WB, IP, IF, IHC(P), ELISAm, r, h, b3
MKLP-1 (24)sc-136473mouse IgG2aN/AWBm, r, h1
MKLP-1 (D-17)sc-33335goat IgGinternal (h)WB, IP, IF, ELISAh, e, c, b, p > r

MKLP-1 CRISPR/Cas9 Knockout Plasmids include:

PRODUCT NAMECAT. #APPLICATIONSSPECIESCITATIONS
MKLP-1 CRISPR/Cas9 KO Plasmid (h)sc-400696gene knockouthumanNEW
MKLP-1 CRISPR/Cas9 KO Plasmid (m)sc-428080gene knockoutmouseNEW

MKLP-1 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAsshRNA PlasmidsshRNA Lentiviral ParticlesCITATIONSRANKING
MKLP-1 siRNA (h): sc-35936MKLP-1 shRNA Plasmid (h):
sc-35936-SH
MKLP-1 shRNA (h)
Lentiviral Particles: sc-35936-V
MKLP-1 siRNA (m): sc-37626MKLP-1 shRNA Plasmid (m):
sc-37626-SH
MKLP-1 shRNA (m)
Lentiviral Particles: sc-37626-V
Not Yet Rated

The monoclonal antibody CHO1 detects a spindle antigen required for mitotic progression. Screening a HeLa cell cDNA expression library with this antibody has been shown to yield a cDNA predicted to encode a protein significantly related within its amino terminal half to the motor ends of members of the kinesin superfamily. Since this similarity does not extend further, it has been suggested that the CHO1 antigen, now designated MKLP-1 (mitotic kinesin-like protein-1), represents a novel kinesin. Sequence analysis has also been shown to predict that MKLP-1 possesses features typical of nuclear proteins. Immunocytological studies have demonstrated that MKLP-1 moves from the nucleus early in mitosis and then to the midbody after cytokinesis. MKLP-1 has been shown to bundle antiparallel microtubules in vitro and to move them at rates comparable to spindle elongation in vivo. A hamster homolog of MKLP-1, designated CHO1 antigen, has also been isolated. Although apparently functionally equivalent with respect to microtubule bundling activity, there are significant differences between the human and hamster proteins at their C-termini, possibly due to alternative splicing or the presence of more than one MKLP-1 locus.