Welcome to Santa Cruz Biotechnology!

MKLP-1 Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of MKLP-1 antibodies. Select MKLP-1 antibodies from several monoclonal and/or polyclonal MKLP-1 antibodies listed below. View detailed MKLP-1 antibody specifications by linking to the specific product blocks. Select appropriate MKLP-1 antibodies for your research by isotype, epitope, applications and species reactivity. MKLP-1 gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle, CRISPR/Cas9 Knockout and CRISPR Double Nickase Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation.

Introducing HOVERcruz™,

a unique system for rapid identification of MKLP-1 Antibodies. Hover over the icon next to the product names in the table to see representative data for that product.

Live chat is now available! (click here)

Our live chat system is available to answer your product and ordering questions.

See chemical MKLP-1 Inhibitors for functional analysis of cellular responses to MKLP-1.

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
MKLP-1 (C-12)
sc-390113mouse IgG11-110 (h)WB, IP, IF, ELISAhumanNEW
MKLP-1 (N-19)
sc-867rabbit IgGN-terminal (h)WB, IP, IF, IHC(P), ELISAh > m, r14
MKLP-1 (Q-16)
sc-33336goat IgGC-terminal (h)WB, IF, ELISAm, r, h, e, c, b, p, a
MKLP-1 (H-110)
sc-22793rabbit IgG1-110 (h)WB, IP, IF, IHC(P), ELISAm, r, h, b3
MKLP-1 (24)
sc-136473mouse IgG2aN/AWBm, r, h1
MKLP-1 (D-17)
sc-33335goat IgGinternal (h)WB, IP, IF, ELISAh, e, c, b, p > r

MKLP-1 CRISPR Knockout, HDR and Nickase Knockout Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
MKLP-1 CRISPR/Cas9 KO Plasmid (h)
sc-400696humanGene KnockoutGFPNEW
MKLP-1 HDR Plasmid (h)
sc-400696-HDRhumanHomology Directed RepairPuromycinNEW
MKLP-1 Double Nickase Plasmid (h)
sc-400696-NIChumanGene KnockoutPuromycinNEW
MKLP-1 Double Nickase Plasmid (h2)
sc-400696-NIC-2humanGene KnockoutPuromycinNEW
MKLP-1 CRISPR/Cas9 KO Plasmid (m)
sc-428080mouseGene KnockoutGFPNEW
MKLP-1 HDR Plasmid (m)
sc-428080-HDRmouseHomology Directed RepairPuromycinNEW
MKLP-1 Double Nickase Plasmid (m)
sc-428080-NICmouseGene KnockoutPuromycinNEW
MKLP-1 Double Nickase Plasmid (m2)
sc-428080-NIC-2mouseGene KnockoutPuromycinNEW

MKLP-1 CRISPR Activation Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
MKLP-1 CRISPR Activation Plasmid (h)
sc-400696-ACThumanGene ActivationZeo, Blast, HygroNEW
MKLP-1 CRISPR Activation Plasmid (h2)
sc-400696-ACT-2humanGene ActivationZeo, Blast, HygroNEW
MKLP-1 Lenti Activation System (h)
sc-400696-LAChumanGene ActivationZeo, Blast, HygroNEW
MKLP-1 Lenti Activation System (h2)
sc-400696-LAC-2humanGene ActivationZeo, Blast, HygroNEW
MKLP-1 CRISPR Activation Plasmid (m)
sc-428080-ACTmouseGene ActivationZeo, Blast, HygroNEW
MKLP-1 CRISPR Activation Plasmid (m2)
sc-428080-ACT-2mouseGene ActivationZeo, Blast, HygroNEW
MKLP-1 Lenti Activation System (m)
sc-428080-LACmouseGene ActivationZeo, Blast, HygroNEW
MKLP-1 Lenti Activation System (m2)
sc-428080-LAC-2mouseGene ActivationZeo, Blast, HygroNEW

MKLP-1 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
MKLP-1 siRNA (h)
sc-35936humanGene SilencingN/A
MKLP-1 shRNA Plasmid (h)
sc-35936-SHhumanGene SilencingPuromycin
MKLP-1 shRNA (h) Lentiviral Particles
sc-35936-VhumanGene SilencingPuromycin
MKLP-1 siRNA (m)
sc-37626mouseGene SilencingN/A
MKLP-1 shRNA Plasmid (m)
sc-37626-SHmouseGene SilencingPuromycin
MKLP-1 shRNA (m) Lentiviral Particles
sc-37626-VmouseGene SilencingPuromycin

The monoclonal antibody CHO1 detects a spindle antigen required for mitotic progression. Screening a HeLa cell cDNA expression library with this antibody has been shown to yield a cDNA predicted to encode a protein significantly related within its amino terminal half to the motor ends of members of the kinesin superfamily. Since this similarity does not extend further, it has been suggested that the CHO1 antigen, now designated MKLP-1 (mitotic kinesin-like protein-1), represents a novel kinesin. Sequence analysis has also been shown to predict that MKLP-1 possesses features typical of nuclear proteins. Immunocytological studies have demonstrated that MKLP-1 moves from the nucleus early in mitosis and then to the midbody after cytokinesis. MKLP-1 has been shown to bundle antiparallel microtubules in vitro and to move them at rates comparable to spindle elongation in vivo. A hamster homolog of MKLP-1, designated CHO1 antigen, has also been isolated. Although apparently functionally equivalent with respect to microtubule bundling activity, there are significant differences between the human and hamster proteins at their C-termini, possibly due to alternative splicing or the presence of more than one MKLP-1 locus.