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megsin Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of megsin antibodies. Select megsin antibodies from several monoclonal and/or polyclonal megsin antibodies listed below. View detailed megsin antibody specifications by linking to the specific product blocks. Select appropriate megsin antibodies for your research by isotype, epitope, applications and species reactivity. megsin gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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a unique system for rapid identification of megsin Antibodies. Hover over product names in the table to see representative data for each product.

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PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
megsin (G-16)sc-79258rabbit IgGInternal (h)WB, IF, ELISAh, r
megsin (D-16)sc-79567goat IgGInternal (m)WB, IF, ELISAm, r
megsin (T-16)sc-79569goat IgGInternal (m)WB, IF, ELISAm, r, e, c, b, p
megsin (I-16)sc-79259rabbit IgGC-terminal (h)WB, IF, ELISAm, h
megsin (N-18)sc-79260rabbit IgGN-terminal (h)WB, IF, ELISAh, e, p

megsin siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAsshRNA PlasmidsshRNA Lentiviral ParticlesCITATIONSRANKING
megsin siRNA (h): sc-75768megsin shRNA Plasmid (h):
sc-75768-SH
megsin shRNA (h)
Lentiviral Particles: sc-75768-V
megsin siRNA (m): sc-75769megsin shRNA Plasmid (m):
sc-75769-SH
megsin shRNA (m)
Lentiviral Particles: sc-75769-V

Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivates proteins that are notably responsible for degradation of extracellular matrix, including MMP-2, MMP-9 and plasmin. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.