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megsin Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of megsin antibodies. Select megsin antibodies from several monoclonal and/or polyclonal megsin antibodies listed below. View detailed megsin antibody specifications by linking to the specific product blocks. Select appropriate megsin antibodies for your research by isotype, epitope, applications and species reactivity. megsin gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle, CRISPR/Cas9 Knockout and CRISPR Double Nickase Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation.

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a unique system for rapid identification of megsin Antibodies. Hover over the icon next to the product names in the table to see representative data for that product.

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PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
megsin (G-16)
sc-79258rabbit IgGInternal (h)WB, IF, ELISAh, r
megsin (D-16)
sc-79567goat IgGInternal (m)WB, IF, ELISAm, r
megsin (T-16)
sc-79569goat IgGInternal (m)WB, IP, IF, ELISAm, r, e, c, b, p
megsin (I-16)
sc-79259rabbit IgGC-terminal (h)WB, IF, ELISAm, h
megsin (N-18)
sc-79260rabbit IgGN-terminal (h)WB, IF, ELISAh, e, p

megsin CRISPR Knockout, HDR and Nickase Knockout Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
megsin CRISPR/Cas9 KO Plasmid (h)
sc-418593humanGene KnockoutGFPNEW
megsin HDR Plasmid (h)
sc-418593-HDRhumanHomology Directed RepairPuromycinNEW
megsin Double Nickase Plasmid (h)
sc-418593-NIChumanGene KnockoutPuromycinNEW
megsin Double Nickase Plasmid (h2)
sc-418593-NIC-2humanGene KnockoutPuromycinNEW
megsin CRISPR/Cas9 KO Plasmid (m)
sc-431160mouseGene KnockoutGFPNEW
megsin HDR Plasmid (m)
sc-431160-HDRmouseHomology Directed RepairPuromycinNEW
megsin Double Nickase Plasmid (m)
sc-431160-NICmouseGene KnockoutPuromycinNEW
megsin Double Nickase Plasmid (m2)
sc-431160-NIC-2mouseGene KnockoutPuromycinNEW

megsin CRISPR Activation Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
megsin CRISPR Activation Plasmid (h)
sc-418593-ACThumanGene ActivationZeo, Blast, HygroNEW
megsin CRISPR Activation Plasmid (h2)
sc-418593-ACT-2humanGene ActivationZeo, Blast, HygroNEW
megsin Lentiviral Activation Particles (h)
sc-418593-LAChumanGene ActivationZeo, Blast, HygroNEW
megsin Lentiviral Activation Particles (h2)
sc-418593-LAC-2humanGene ActivationZeo, Blast, HygroNEW
megsin CRISPR Activation Plasmid (m)
sc-431160-ACTmouseGene ActivationZeo, Blast, HygroNEW
megsin CRISPR Activation Plasmid (m2)
sc-431160-ACT-2mouseGene ActivationZeo, Blast, HygroNEW
megsin Lentiviral Activation Particles (m)
sc-431160-LACmouseGene ActivationZeo, Blast, HygroNEW
megsin Lentiviral Activation Particles (m2)
sc-431160-LAC-2mouseGene ActivationZeo, Blast, HygroNEW

megsin siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
megsin siRNA (h)
sc-75768humanGene SilencingN/A
megsin shRNA Plasmid (h)
sc-75768-SHhumanGene SilencingPuromycin
megsin shRNA (h) Lentiviral Particles
sc-75768-VhumanGene SilencingPuromycin
megsin siRNA (m)
sc-75769mouseGene SilencingN/A
megsin shRNA Plasmid (m)
sc-75769-SHmouseGene SilencingPuromycin
megsin shRNA (m) Lentiviral Particles
sc-75769-VmouseGene SilencingPuromycin

Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivates proteins that are notably responsible for degradation of extracellular matrix, including MMP-2, MMP-9 and plasmin. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.