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megsin Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of megsin antibodies. Select megsin antibodies from several monoclonal and/or polyclonal megsin antibodies listed below. View detailed megsin antibody specifications by linking to the specific product blocks. Select appropriate megsin antibodies for your research by isotype, epitope, applications and species reactivity. megsin gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle and CRISPR/Cas9 Knockout Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids for gene activation.

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a unique system for rapid identification of megsin Antibodies. Hover over product names in the table to see representative data for each product.

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megsin (G-16)sc-79258rabbit IgGInternal (h)WB, IF, ELISAh, r
megsin (D-16)sc-79567goat IgGInternal (m)WB, IF, ELISAm, r
megsin (T-16)sc-79569goat IgGInternal (m)WB, IP, IF, ELISAm, r, e, c, b, p
megsin (I-16)sc-79259rabbit IgGC-terminal (h)WB, IF, ELISAm, h
megsin (N-18)sc-79260rabbit IgGN-terminal (h)WB, IF, ELISAh, e, p

megsin CRISPR Plasmids include:

Knockout PlasmidsHDR PlasmidsActivation PlasmidsCITATIONSRATING
megsin CRISPR/Cas9 KO Plasmid (h):
megsin HDR Plasmid (h):
megsin Activation Plasmid (h):
NEWNot Yet Rated
megsin CRISPR/Cas9 KO Plasmid (m):
megsin HDR Plasmid (m):
megsin Activation Plasmid (m):
NEWNot Yet Rated

megsin siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAsshRNA PlasmidsshRNA Lentiviral ParticlesCITATIONSRATING
megsin siRNA (h): sc-75768megsin shRNA Plasmid (h):
megsin shRNA (h)
Lentiviral Particles: sc-75768-V
Not Yet Rated
megsin siRNA (m): sc-75769megsin shRNA Plasmid (m):
megsin shRNA (m)
Lentiviral Particles: sc-75769-V
Not Yet Rated

Megsin, also designated SerpinB7 and TP55, is a 380 amino acid cytoplasmic protein that is predominantly expressed in mesangial cells, which play an important role in maintaining glomerular structure and function. As a member of the serpin family, megsin is a serine protesase inhibitor which potentially inactivates proteins that are notably responsible for degradation of extracellular matrix, including MMP-2, MMP-9 and plasmin. Overexpression of megsin results in an increase in number of mesangial cells and therefore a progressive mesangial matrix expansion, which is accompanied by immune complex deposition. This finding suggests that megsin significantly influences the role of mesangial cells in renal structure and is likely implicated in a variety of nephropathies.