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LOC283999 AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of LOC283999 antibodies. Select LOC283999 antibodies from several monoclonal and/or polyclonal LOC283999 antibodies listed below. View detailed LOC283999 antibody specifications by linking to the specific product blocks. Select appropriate LOC283999 antibodies for your research by isotype, epitope, applications and species reactivity. LOC283999 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of LOC283999 Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
LOC283999 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
LOC283999, also known as TMEM235 (transmembrane protein 235), is a 223 amino acid multi-pass membrane protein that localized to the endoplasmic reticulum. Belonging to the PMP-22/EMP/MP20 family, LOC283999 exists as three alternatively spliced isoforms and is encoded by a gene located on human chromosome 17q25.1. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. |
