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Lck BP-1 AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of Lck BP-1 antibodies. Select Lck BP-1 antibodies from several monoclonal and/or polyclonal Lck BP-1 antibodies listed below. View detailed Lck BP-1 antibody specifications by linking to the specific product blocks. Select appropriate Lck BP-1 antibodies for your research by isotype, epitope, applications and species reactivity. Lck BP-1 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of Lck BP-1 Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
Lck BP-1 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
A total of eight membrane-associated tyrosine protein kinases have been identified within the Src gene family. These include c-Src, c-Yes, Fyn, Lck, Hck, Lyn, Blk and c-Fgr. The major translational product of the human Lck gene is a lymphocyte-specific tyrosine kinase designated pp56Lck. This is a membrane-associated molecule, most likely via covalently associated myristate at the amino terminus. The Lck gene has been shown to undergo rearrangement and overexpression in some murine lymphomas. In human studies, it has been demonstrated that the Lck gene is localized to a site in the genome which undergoes frequent chromosomal abnormalities in lymphomas and neuroblastomas. A novel Lck signaling intermediate, designated Lck BP-1, associates directly with the Lck SH3 domian via two proline-rich regions. Lck BP-1 also contains four tandem 37 amino acid repeats that form a putative helix-loop-helix DNA binding motif. Immunoprecipitation studies have shown that Lck BP-1 will co-immunoprecipitate with Lck from T cell lysates. Lck BP-1 is tyrosine phosphorylated in T cells subsequent to TCR activation. |
