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Las17 AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of Las17 antibodies. Select Las17 antibodies from several monoclonal and/or polyclonal Las17 antibodies listed below. View detailed Las17 antibody specifications by linking to the specific product blocks. Select appropriate Las17 antibodies for your research by isotype, epitope, applications and species reactivity. Introducing HOVERcruz™,a unique system for rapid identification of Las17 Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
Several processes, including cell motility and cell polarization, require the generation of cortical actin filaments. In Saccharomyces cerevisiae, actin-related proteins Arp2 and Arp3, essential components of the actin cytoskeleton, form a complex that localizes to cortical actin patches, which are required for polarized cell growth. A high molecular weight protein complex, which includes Las17, Myo3, Myo5, and Vrp1, regulates Arp2/Arp3 complex-dependent actin polymerization. Las17, also designated Bee1, is the yeast homolog of human WASP (Wiskott-Aldrich syndrome protein), a disorder characterized by immuno-deficiencies and defects in blood cell morphogenesis. Deletion of Las17 produces a change in the organization of actin filaments, and results in defects in budding and cytokinesis. Las17 interacts with several proteins associated with the actin filament to mediate cell motility functions, such as endocytosis, polarized morphogenesis, and cell migration. |
