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Hus AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of Hus antibodies. Select Hus antibodies from several monoclonal and/or polyclonal Hus antibodies listed below. View detailed Hus antibody specifications by linking to the specific product blocks. Select appropriate Hus antibodies for your research by isotype, epitope, applications and species reactivity. Hus gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of Hus Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional Hus Antibodies including, Hus1, Hus1B
Hus siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
Hus1B (checkpoint protein Hus1B) is a 276 amino acid protein encoded by the human gene HUS1B. Hus1B is a paralog of the human cell cycle checkpoint gene HUS1. Hus1B is expressed variably in many human tissues, and the tissue-specific levels observed parallel those for Hus1. A Hus1-Rad1-Rad9 protein complex is thought to form a proliferating cell nuclear antigen (PCNA)-like structure, important for cell cycle checkpoint function. However, Hus1B directly interacts with Rad1, but not Rad9 or Hus1, whereas Hus1 can bind Rad1, Rad9, and another molecule of Hus1, suggesting that Hus1B cannot simply substitute for Hus1 in the complex. Hus1B is less conserved evolutionarily than Hus1 and overexpression of Hus1B, but not Hus1, in human cells induces clonogenic cell death. It is believed that Hus1B and Hus1 have distinct but related roles in regulating cell cycle checkpoints and genomic integrity. |
