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HUGT Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of HUGT antibodies. Select HUGT antibodies from several monoclonal and/or polyclonal HUGT antibodies listed below. View detailed HUGT antibody specifications by linking to the specific product blocks. Select appropriate HUGT antibodies for your research by isotype, epitope, applications and species reactivity. HUGT gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle and CRISPR/Cas9 Knockout Plasmid formats are also available.

Introducing HOVERcruz™,

a unique system for rapid identification of HUGT Antibodies. Hover over product names in the table to see representative data for each product.

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PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
HUGT2 (N-16)sc-84312rabbit IgGN-terminal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p
HUGT2 (H-180)sc-366924rabbit IgG681-860 (h)WB, IP, IF, ELISAm, r, hNEW
HUGT2 (I-18)sc-84311rabbit IgGInternal (h)WB, IF, ELISAm, h

HUGT CRISPR/Cas9 Knockout Plasmids include:

PRODUCT NAMECAT. #APPLICATIONSSPECIESCITATIONS
HUGT2 CRISPR/Cas9 KO Plasmid (h)sc-407545gene knockouthumanNEW
HUGT2 CRISPR/Cas9 KO Plasmid (m)sc-426019gene knockoutmouseNEW

HUGT siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAsshRNA PlasmidsshRNA Lentiviral ParticlesCITATIONSRANKING
HUGT2 siRNA (h): sc-75315HUGT2 shRNA Plasmid (h):
sc-75315-SH
HUGT2 shRNA (h)
Lentiviral Particles: sc-75315-V
Not Yet Rated
HUGT2 siRNA (m): sc-146114HUGT2 shRNA Plasmid (m):
sc-146114-SH
HUGT2 shRNA (m)
Lentiviral Particles: sc-146114-V
Not Yet Rated

HUGT2 is also known as UGCGL2 (UDP-glucose ceramide glucosyltransferase-like 2) or UGT2 (UDP-glucose: glycoprotein glucosyltransferase 2) and is a 1,516 amino acid protein that is expressed abundantly in kidney, pancreas, heart and skeletal muscle. HUGT2 is localized to the lumen of the ER (endoplasmic reticulum) and to the ER-Golgi intermediate compartment which regulates transportation between the ER and the Golgi. HUGT2 is a quality control protein that targets unfolded glycoproteins for glucosylation in a calcium-dependent manner, but may use manganese is the absence of calcium. HUGT2 targets glycans by attaching single glucose residues to glycans with amino acid sequences which are not correctly folded, an enzymatic process that is exhibited during carbohydrate processing. Patients with type 2 diabetes express altered HUGT2 proteins in their β cells, suggesting that these patients may also have defects in their ER glycoprotein quality control abilities.