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HUGT Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of HUGT antibodies. Select HUGT antibodies from several monoclonal and/or polyclonal HUGT antibodies listed below. View detailed HUGT antibody specifications by linking to the specific product blocks. Select appropriate HUGT antibodies for your research by isotype, epitope, applications and species reactivity. HUGT gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle and CRISPR/Cas9 Knockout Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids for gene activation.

Introducing HOVERcruz™,

a unique system for rapid identification of HUGT Antibodies. Hover over product names in the table to see representative data for each product.

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PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
HUGT2 (N-16)sc-84312rabbit IgGN-terminal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p
HUGT2 (H-180)sc-366924rabbit IgG681-860 (h)WB, IP, IF, ELISAm, r, hNEW
HUGT2 (I-18)sc-84311rabbit IgGInternal (h)WB, IF, ELISAm, h

HUGT CRISPR Knockout and HDR Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
HUGT2 CRISPR/Cas9 KO Plasmid (h)sc-407545humanGene KnockoutNEWNot Yet Rated
HUGT2 HDR Plasmid (h)sc-407545-HDRhumanHomology Directed RepairNEWNot Yet Rated
HUGT2 CRISPR/Cas9 KO Plasmid (m)sc-426019mouseGene KnockoutNEWNot Yet Rated
HUGT2 HDR Plasmid (m)sc-426019-HDRmouseHomology Directed RepairNEWNot Yet Rated

HUGT CRISPR Activation Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
HUGT2 CRISPR Activation Plasmid (h)sc-407545-ACThumanGene ActivationNEWNot Yet Rated
HUGT2 CRISPR Activation Plasmid (m)sc-426019-ACTmouseGene ActivationNEWNot Yet Rated

HUGT siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
HUGT2 siRNA (h)sc-75315humanGene SilencingNot Yet Rated
HUGT2 shRNA Plasmid (h)sc-75315-SHhumanGene SilencingNot Yet Rated
HUGT2 shRNA (h) Lentiviral Particlessc-75315-VhumanGene SilencingNot Yet Rated
HUGT2 siRNA (m)sc-146114mouseGene SilencingNot Yet Rated
HUGT2 shRNA Plasmid (m)sc-146114-SHmouseGene SilencingNot Yet Rated
HUGT2 shRNA (m) Lentiviral Particlessc-146114-VmouseGene SilencingNot Yet Rated

HUGT2 is also known as UGCGL2 (UDP-glucose ceramide glucosyltransferase-like 2) or UGT2 (UDP-glucose: glycoprotein glucosyltransferase 2) and is a 1,516 amino acid protein that is expressed abundantly in kidney, pancreas, heart and skeletal muscle. HUGT2 is localized to the lumen of the ER (endoplasmic reticulum) and to the ER-Golgi intermediate compartment which regulates transportation between the ER and the Golgi. HUGT2 is a quality control protein that targets unfolded glycoproteins for glucosylation in a calcium-dependent manner, but may use manganese is the absence of calcium. HUGT2 targets glycans by attaching single glucose residues to glycans with amino acid sequences which are not correctly folded, an enzymatic process that is exhibited during carbohydrate processing. Patients with type 2 diabetes express altered HUGT2 proteins in their β cells, suggesting that these patients may also have defects in their ER glycoprotein quality control abilities.