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HUGT Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of HUGT antibodies. Select HUGT antibodies from several monoclonal and/or polyclonal HUGT antibodies listed below. View detailed HUGT antibody specifications by linking to the specific product blocks. Select appropriate HUGT antibodies for your research by isotype, epitope, applications and species reactivity. HUGT gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle, CRISPR/Cas9 Knockout and CRISPR Double Nickase Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation.

Introducing HOVERcruz™,

a unique system for rapid identification of HUGT Antibodies. Hover over the icon next to the product names in the table to see representative data for that product.

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Our live chat system is available to answer your product and ordering questions.

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
HUGT2 (N-16)
sc-84312rabbit IgGN-terminal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p
HUGT2 (H-180)
sc-366924rabbit IgG681-860 (h)WB, IP, IF, ELISAm, r, hNEW
HUGT2 (I-18)
sc-84311rabbit IgGInternal (h)WB, IF, ELISAm, h

HUGT CRISPR Knockout, HDR and Nickase Knockout Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
HUGT2 CRISPR/Cas9 KO Plasmid (h)
sc-407545humanGene KnockoutGFPNEW
HUGT2 HDR Plasmid (h)
sc-407545-HDRhumanHomology Directed RepairPuromycinNEW
HUGT2 Double Nickase Plasmid (h)
sc-407545-NIChumanGene KnockoutPuromycinNEW
HUGT2 Double Nickase Plasmid (h2)
sc-407545-NIC-2humanGene KnockoutPuromycinNEW
HUGT2 CRISPR/Cas9 KO Plasmid (m)
sc-426019mouseGene KnockoutGFPNEW
HUGT2 HDR Plasmid (m)
sc-426019-HDRmouseHomology Directed RepairPuromycinNEW
HUGT2 Double Nickase Plasmid (m)
sc-426019-NICmouseGene KnockoutPuromycinNEW
HUGT2 Double Nickase Plasmid (m2)
sc-426019-NIC-2mouseGene KnockoutPuromycinNEW

HUGT CRISPR Activation Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
HUGT2 CRISPR Activation Plasmid (h)
sc-407545-ACThumanGene ActivationZeo, Blast, HygroNEW
HUGT2 CRISPR Activation Plasmid (h2)
sc-407545-ACT-2humanGene ActivationZeo, Blast, HygroNEW
HUGT2 Lentiviral Activation Particles (h)
sc-407545-LAChumanGene ActivationZeo, Blast, HygroNEW
HUGT2 Lentiviral Activation Particles (h2)
sc-407545-LAC-2humanGene ActivationZeo, Blast, HygroNEW
HUGT2 CRISPR Activation Plasmid (m)
sc-426019-ACTmouseGene ActivationZeo, Blast, HygroNEW
HUGT2 CRISPR Activation Plasmid (m2)
sc-426019-ACT-2mouseGene ActivationZeo, Blast, HygroNEW
HUGT2 Lentiviral Activation Particles (m)
sc-426019-LACmouseGene ActivationZeo, Blast, HygroNEW
HUGT2 Lentiviral Activation Particles (m2)
sc-426019-LAC-2mouseGene ActivationZeo, Blast, HygroNEW

HUGT siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSMARKERCITATIONS
HUGT2 siRNA (h)
sc-75315humanGene SilencingN/A
HUGT2 shRNA Plasmid (h)
sc-75315-SHhumanGene SilencingPuromycin
HUGT2 shRNA (h) Lentiviral Particles
sc-75315-VhumanGene SilencingPuromycin
HUGT2 siRNA (m)
sc-146114mouseGene SilencingN/A
HUGT2 shRNA Plasmid (m)
sc-146114-SHmouseGene SilencingPuromycin
HUGT2 shRNA (m) Lentiviral Particles
sc-146114-VmouseGene SilencingPuromycin

HUGT2 is also known as UGCGL2 (UDP-glucose ceramide glucosyltransferase-like 2) or UGT2 (UDP-glucose: glycoprotein glucosyltransferase 2) and is a 1,516 amino acid protein that is expressed abundantly in kidney, pancreas, heart and skeletal muscle. HUGT2 is localized to the lumen of the ER (endoplasmic reticulum) and to the ER-Golgi intermediate compartment which regulates transportation between the ER and the Golgi. HUGT2 is a quality control protein that targets unfolded glycoproteins for glucosylation in a calcium-dependent manner, but may use manganese is the absence of calcium. HUGT2 targets glycans by attaching single glucose residues to glycans with amino acid sequences which are not correctly folded, an enzymatic process that is exhibited during carbohydrate processing. Patients with type 2 diabetes express altered HUGT2 proteins in their β cells, suggesting that these patients may also have defects in their ER glycoprotein quality control abilities.