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Hexosaminidase AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of Hexosaminidase antibodies. Select Hexosaminidase antibodies from several monoclonal and/or polyclonal Hexosaminidase antibodies listed below. View detailed Hexosaminidase antibody specifications by linking to the specific product blocks. Select appropriate Hexosaminidase antibodies for your research by isotype, epitope, applications and species reactivity. Hexosaminidase gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of Hexosaminidase Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional Hexosaminidase Antibodies including, HEXA, HEXB, HEXB A chain, HEXB B chain
Hexosaminidase siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
Hexosaminidase B (HEXB), also designated β-hexosaminidase B, is a Hexosaminidase B (HEXB), also designated b-hexosaminidase B, is a tetramer of two β--A and two β-B chains and is found in the lysosomes of cells. Sandhoff disease (SD), also known as GM2-gangliosidosis type II, is caused by mutations in the HEXB gene that affect the β subunit. These mutations disrupt the activity of HEXB and HEXA, which prevents the breakdown of GM2 ganglioside, a fatty material found in the brain, therby rendering both the HEXA and HEXB enzymes deficient. SD is a rare autosomal recessive disorder characterized by an accumulation of GM2 ganglioside, which causes progressive destruction of the central nervous system. Sandhoff disease is similar to Tay-Sachs disease, which is caused by mutations in the HEXA gene, although SD is more severe. |
