HEL308 Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of HEL308 antibodies. Select HEL308 antibodies from several monoclonal and/or polyclonal HEL308 antibodies listed below. View detailed HEL308 antibody specifications by linking to the specific product blocks. Select appropriate HEL308 antibodies for your research by isotype, epitope, applications and species reactivity. HEL308 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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PRODUCT NAME	CAT. #	ISOTYPE	EPITOPE	APPLICATIONS	SPECIES
HEL308 (N-15)	sc-104306	goat IgG	N-terminal (h)	WB, IF, ELISA	human
HEL308 (K-17)	sc-104305	goat IgG	Internal (h)	WB, IP, IF, ELISA	m, r, h, e, c, b, p, a
HEL308 (C-17)	sc-104303	goat IgG	C-terminal (h)	WB, IF, ELISA	m, r, h, e, c, b, p, a
HEL308 (H-239)	sc-98400	rabbit IgG	830-1068 (h)	WB, IP, IF, ELISA	m, r, h, e, c, b, p
HEL308 (2406C1a)	sc-81095	mouse IgG₁	Internal (h)	WB, IP	human

HEL308 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAs	shRNA Plasmids	shRNA Lentiviral Particles	CITATIONS	RANKING
HEL308 siRNA (h): sc-89305	HEL308 shRNA Plasmid (h): sc-89305-SH	HEL308 shRNA (h) Lentiviral Particles: sc-89305-V
HEL308 siRNA (m): sc-105447	HEL308 shRNA Plasmid (m): sc-105447-SH	HEL308 shRNA (m) Lentiviral Particles: sc-105447-V

HEL308, a DNA repair helicase, is a member of the helicase superfamily 2 and is conserved in eukaryotes and archaea. The human HEL308 gene encodes for a single stranded, 1101 amino acid protein that acts as a DNA dependent ATPase. HEL308 is expressed in ovaries, heart, spleen, thymus, prostate, liver, kidney, and pancreas. It is highly expressed in the testis. During the early stages of DNA recombination, HEL308 plays a critical role in DNA crosslink repair following replication fork arrest. HEL308 is believed to aid in restarting DNA replication by displacing the lagging strand at the stalled replication forks.. Human HEL308 shares homology with the Hel308 locus in Mus musculus and the mus308 locus in Drosophila melanogaster. In adult mice, Hel308 is only expressed in primary spermatocytes in seminiferous tubules of testis. The mus308 gene in D. melanogaster encodes a protein with structural characteristics of both DNA polymerases and helicases. The gene product may also be involved in the repair of lesions other than crosslinks.