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HDAC Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of HDAC antibodies. Select HDAC antibodies from several monoclonal and/or polyclonal HDAC antibodies listed below. View detailed HDAC antibody specifications by linking to the specific product blocks. Select appropriate HDAC antibodies for your research by isotype, epitope, applications and species reactivity. HDAC gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle and CRISPR/Cas9 Knockout Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids for gene activation.

Introducing HOVERcruz™,

a unique system for rapid identification of HDAC Antibodies. Hover over product names in the table to see representative data for each product.

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See chemical HDAC Inhibitors, chemical HDAC Activators or chemical HDAC Substrates for functional analysis of cellular responses to HDAC.

Also see additional HDAC Antibodies including, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7... See More, HDAC8, HDAC9, HDAC10, HDAC11

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
HDAC1 (10E2)sc-81598mouse IgG1467-482 (h)WB, IP, IF, IHC(P)m, r, h6
HDAC1 (C-19)sc-6298goat IgGC-terminal (h)WB, IP, IF, IHC(P), ELISAm, r, h64
HDAC1 (H-11)sc-8410mouse IgG1432-482 (h)WB, IP, IF, FCM, ELISAm, r, h56
HDAC1 (H-51)sc-7872rabbit IgG432-482 (h)WB, IP, IF, IHC(P), ELISAm, r, h, c, b, p, e147
HDAC1 (N-19)sc-6299goat IgGN-terminal (h)WB, IP, IF, IHC(P), ELISAm, r, h, zebrafish, Xenopus, c, b, a11
HDAC2 (3F3)sc-81599mouse IgG1473-488 (h)WB, IP, IFm, r, h, b5
HDAC2 (B-2)sc-55541mouse IgG1435-488 (h)WB, IP, IF, ELISAm, h2
HDAC2 (C-19)sc-6296goat IgGC-terminal (h)WB, IP, IF, IHC(P), FCM, ELISAm, r, h, e, b, p, c, a33
HDAC2 (C-8)sc-9959mouse IgG435-488 (h)WB, IP, IF, IHC(P)m, h32
HDAC2 (F-6)sc-55542mouse IgG1435-488 (h)WB, IP, IF, ELISAm, h1
HDAC2 (H-54)sc-7899rabbit IgG435-488 (h)WB, IP, IF, IHC(P), ELISAm, r, h, c, b, p, a, e104
HDAC2 (HDAC2-62)sc-56685mouse IgG2b471-488 (h)WB, IP, IFm, r, h
HDAC3 (A-3)sc-376957mouse IgG12-29 (h)WB, IP, IF, ELISAh, e, c, b, p, a
HDAC3 (3G6)sc-81600mouse IgG2a411-428 (h)WB, IP, IF, IHC(P)m, h1
HDAC3 (1)sc-130319mouse IgG1FL (h)WB, ELISAhuman1
HDAC3 (B-12)sc-17795mouse IgG2a330-428 (h)WB, IP, IF, ELISAm, r, h, e, c, b, p13
HDAC3 (H-99)sc-11417rabbit IgG330-428 (h)WB, IP, IF, IHC(P), ELISAm, r, h, e, c, b, p, a85
HDAC3 (N-19)sc-8138goat IgGN-terminal (h)WB, IP, IF, ELISAh, e, c, b, p, a, Drosophila23
HDAC3 (40)sc-136290mouse IgG1N/AWB, IP, IFm, r, h
HDAC4 (B-5)sc-365093mouse IgG2b2-23 (h)WB, IP, IF, ELISAm, r, h, a
HDAC4 (A-4)sc-46672mouse IgG2b530-631(h)WB, IP, IF, IHC(P), ELISAm, h5
HDAC4 (F-6)sc-365367mouse IgG2a2-23 (h)WB, IP, IF, ELISAm, r, h, a1
HDAC4 (D-1)sc-48390mouse IgG1530-631 (h)WB, IP, IF, IHC(P), ELISAm, h
HDAC4 (H-92)sc-11418rabbit IgG530-631 (h)WB, IP, IF, IHC(P), ELISAm, r, h35
HDAC4 (L-19)sc-5246goat IgGN-terminal (h) WB, IP, IF, IHC(P), ELISAm, h, r, b7
HDAC4 (N-18)sc-5245goat IgGN-terminal (h) WB, IP, IF, IHC(P), ELISAm, h, r, a6
HDAC4 (HDAC-144)sc-56686mouse IgG2a1-19 (h)WB, IP, IFm, r, h
HDAC5 (B-11)sc-133106mouse IgG2b371-443 (h)WB, IP, IF, IHC(P), ELISAh, r2
HDAC5 (C-11)sc-133225mouse IgG2b371-443 (h)WB, IP, IF, IHC(P), ELISAm, r, h1
HDAC5 (G-18)sc-5250goat IgGinternal (h)WB, IP, IF, ELISAm, r, h7
HDAC5 (H-74)sc-11419rabbit IgG371-443 (h)WB, IP, IF, ELISAm, r, h, e, c, b14
HDAC5 (P-16)sc-5252goat IgGinternal (m)WB, IP, IF, IHC(P), ELISAm, r, h, e, c, b5
HDAC6 (D-11)sc-28386mouse IgG2a916-1215 (h)WB, IP, IF, IHC(P), ELISAhuman5
HDAC6 (H-300)sc-11420rabbit IgG916-1215 (h)WB, IP, IF, IHC(P), ELISAhuman39
HDAC6 (L-18)sc-5258goat IgGN-terminal (m)WB, IP, IF, IHC(P), ELISAm, r, h8
HDAC6 (S-14)sc-5255goat IgGN-terminal (h)WB, IP, IF, IHC(P), ELISAhuman3
HDAC4/5/7 (H-273)sc-11421rabbit IgG163-435 (h)WB, IP, IF, IHC(P), ELISAm, r, h15
HDAC7 (A-7)sc-74563mouse IgG2a163-435 (h)WB, IP, IF, ELISAhuman1
HDAC7 (L-19)sc-11493goat IgGinternal (m)WB, IP, IF, ELISAm, r > h
HDAC7 (C-18)sc-11491goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h6
HDAC7 (N-18)sc-11489goat IgGN-terminal (h)WB, IP, IF, IHC(P), ELISAm, r, h, c, b4
HDAC8 (B-4)sc-365620mouse IgG12-28 (h)WB, IP, IF, IHC(P), ELISAh > m, r
HDAC8 (E-5)sc-17778mouse IgG2b1-145 (h)WB, IP, IF, ELISAhuman6
HDAC8 (F-9)sc-374180mouse IgG32-28 (h)WB, IP, IF, ELISAh > m, r
HDAC8 (H-145)sc-11405rabbit IgG1-145 (h)WB, IP, IF, ELISAm, r, h, c, b, p, e16
HDAC8 (N-20)sc-11544goat IgGN-terminal (h)WB, IP, IF, IHC(P), ELISAh, e, c, b, p > m, r4
HDAC9 (B-1)sc-398003mouse IgM12-39 (h)WB, IP, IF, ELISAm, r, hNEW
HDAC8 (HDAC8-48)sc-56687mouse IgG1FL (h)WB, ELISAhuman
HDAC9 (H-45)sc-28732rabbit IgG1-45 (h)WB, IP, IF, ELISAm, r, h, e, c, p4
HDAC9 (G-15)sc-10408goat IgGN-terminal (h)WB, IF, ELISAm, r, h, e, c, b, p, a2
HDAC9 (N-20)sc-32094goat IgGN-terminal (h)WB, IP, IF, ELISAm, r, h, e, c, b, p, a
HDAC9 (P-17)sc-32095goat IgGinternal (h)WB, IF, ELISAm, r, h, e, c, b, p
HDAC9 (V-16)sc-30744goat IgGinternal (h)WB, IF, ELISAm, h, e, c, p, a
HDAC10 (D-9)sc-365270mouse IgG157-85 (h)WB, IP, IF, ELISAm, r, h1
HDAC10 (E-2)sc-393417mouse IgG2a62-116 (m)WB, IP, IF, ELISAm, hNEW
HDAC10 (F-4)sc-376121mouse IgG161-116 (h)WB, IP, IF, ELISAhuman
HDAC10 (H-56)sc-134995rabbit IgG61-116 (h)WB, IP, IF, ELISAh, e > m, r
HDAC10 (K-17)sc-54213goat IgGInternal (m)WB, IF, ELISAm, rNEW
HDAC10 (S-17)sc-54215goat IgGInternal (h)WB, IP, IF, ELISAhuman
HDAC10 (M-55)sc-134996rabbit IgG62-116 (m)WB, IP, IF, ELISAm, r > h
HDAC10 (N-20)sc-54214goat IgGN-terminal (h)WB, IF, ELISAm, r, hNEW
HDAC10 (Y-24)sc-130775rabbit IgGN/AWB, IP, ELISAm, h
HDAC11 (N-20)sc-54219goat IgGN-terminal (h)WB, IP, IF, ELISAm, r, h, e, b, p
HDAC11 (C-5)sc-390737mouse IgG2b (h)WB, IP, IF, ELISAhumanNEW
HDAC11 (S-15)sc-54220goat IgGN-terminal (h)WB, IF, ELISAm, r, h, e, b, p
HDAC11 (H-300)sc-292834rabbit IgG1-300 (h)WB, IP, IF, ELISAm, r, h
HDAC11 (Y-25)sc-130776rabbit IgGN/AWB, IP, IF, IHC(P), ELISAm, h1

Phospho-Specific HDAC Antibodies

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
p-HDAC2 (Ser 394)sc-135639rabbit IgGN/AWB, IP, IF, IHC(P)m, h2
p-HDAC4 (Ser 632)sc-101691rabbit IgGSer 632 (h)WB, IPm, r, h
p-HDAC5 (Ser 498)sc-101692rabbit IgGSer 498 (h)WB, IP, IF, IHC(P)m, h1
p-HDAC8 (Ser 39)sc-101693rabbit IgGSer 39 (h)IF, IHC(P)m, r, h1
p-HDAC4/5/9 (Ser 246/259/220)sc-135656rabbit IgGN/AWB, IPm, h

HDAC CRISPR Knockout and HDR Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
HDAC1 CRISPR/Cas9 KO Plasmid (h)sc-400203humanGene KnockoutNEWNot Yet Rated
HDAC1 HDR Plasmid (h)sc-400203-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC2 CRISPR/Cas9 KO Plasmid (h)sc-400303humanGene KnockoutNEWNot Yet Rated
HDAC2 HDR Plasmid (h)sc-400303-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC6 CRISPR/Cas9 KO Plasmid (h)sc-400314humanGene KnockoutNEWNot Yet Rated
HDAC6 HDR Plasmid (h)sc-400314-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC4 CRISPR/Cas9 KO Plasmid (h)sc-400388humanGene KnockoutNEWNot Yet Rated
HDAC4 HDR Plasmid (h)sc-400388-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC3 CRISPR/Cas9 KO Plasmid (h)sc-400446humanGene KnockoutNEWNot Yet Rated
HDAC3 HDR Plasmid (h)sc-400446-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC5 CRISPR/Cas9 KO Plasmid (h)sc-400659humanGene KnockoutNEWNot Yet Rated
HDAC5 HDR Plasmid (h)sc-400659-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC8 CRISPR/Cas9 KO Plasmid (h)sc-400757humanGene KnockoutNEWNot Yet Rated
HDAC8 HDR Plasmid (h)sc-400757-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC7 CRISPR/Cas9 KO Plasmid (h)sc-400989humanGene KnockoutNEWNot Yet Rated
HDAC7 HDR Plasmid (h)sc-400989-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC9 CRISPR/Cas9 KO Plasmid (h)sc-401419humanGene KnockoutNEWNot Yet Rated
HDAC9 HDR Plasmid (h)sc-401419-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC11 CRISPR/Cas9 KO Plasmid (h)sc-402103humanGene KnockoutNEWNot Yet Rated
HDAC11 HDR Plasmid (h)sc-402103-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC10 CRISPR/Cas9 KO Plasmid (h)sc-403221humanGene KnockoutNEWNot Yet Rated
HDAC10 HDR Plasmid (h)sc-403221-HDRhumanHomology Directed RepairNEWNot Yet Rated
HDAC2 CRISPR/Cas9 KO Plasmid (m)sc-420817mouseGene KnockoutNEWNot Yet Rated
HDAC2 HDR Plasmid (m)sc-420817-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC3 CRISPR/Cas9 KO Plasmid (m)sc-420818mouseGene KnockoutNEWNot Yet Rated
HDAC3 HDR Plasmid (m)sc-420818-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC5 CRISPR/Cas9 KO Plasmid (m)sc-420819mouseGene KnockoutNEWNot Yet Rated
HDAC5 HDR Plasmid (m)sc-420819-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC6 CRISPR/Cas9 KO Plasmid (m)sc-420820mouseGene KnockoutNEWNot Yet Rated
HDAC6 HDR Plasmid (m)sc-420820-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC7 CRISPR/Cas9 KO Plasmid (m)sc-425052mouseGene KnockoutNEWNot Yet Rated
HDAC7 HDR Plasmid (m)sc-425052-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC8 CRISPR/Cas9 KO Plasmid (m)sc-427666mouseGene KnockoutNEWNot Yet Rated
HDAC8 HDR Plasmid (m)sc-427666-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC9 CRISPR/Cas9 KO Plasmid (m)sc-429766mouseGene KnockoutNEWNot Yet Rated
HDAC9 HDR Plasmid (m)sc-429766-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC10 CRISPR/Cas9 KO Plasmid (m)sc-431327mouseGene KnockoutNEWNot Yet Rated
HDAC10 HDR Plasmid (m)sc-431327-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC4 CRISPR/Cas9 KO Plasmid (m)sc-431586mouseGene KnockoutNEWNot Yet Rated
HDAC4 HDR Plasmid (m)sc-431586-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC11 CRISPR/Cas9 KO Plasmid (m)sc-433149mouseGene KnockoutNEWNot Yet Rated
HDAC11 HDR Plasmid (m)sc-433149-HDRmouseHomology Directed RepairNEWNot Yet Rated
HDAC1 CRISPR/Cas9 KO Plasmid (m)sc-436647mouseGene KnockoutNEWNot Yet Rated
HDAC1 HDR Plasmid (m)sc-436647-HDRmouseHomology Directed RepairNEWNot Yet Rated

HDAC CRISPR Activation Plasmids include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
HDAC1 CRISPR Activation Plasmid (h)sc-400203-ACThumanGene ActivationNEWNot Yet Rated
HDAC2 CRISPR Activation Plasmid (h)sc-400303-ACThumanGene ActivationNEWNot Yet Rated
HDAC6 CRISPR Activation Plasmid (h)sc-400314-ACThumanGene ActivationNEWNot Yet Rated
HDAC4 CRISPR Activation Plasmid (h)sc-400388-ACThumanGene ActivationNEWNot Yet Rated
HDAC3 CRISPR Activation Plasmid (h)sc-400446-ACThumanGene ActivationNEWNot Yet Rated
HDAC5 CRISPR Activation Plasmid (h)sc-400659-ACThumanGene ActivationNEWNot Yet Rated
HDAC8 CRISPR Activation Plasmid (h)sc-400757-ACThumanGene ActivationNEWNot Yet Rated
HDAC7 CRISPR Activation Plasmid (h)sc-400989-ACThumanGene ActivationNEWNot Yet Rated
HDAC9 CRISPR Activation Plasmid (h)sc-401419-ACThumanGene ActivationNEWNot Yet Rated
HDAC11 CRISPR Activation Plasmid (h)sc-402103-ACThumanGene ActivationNEWNot Yet Rated
HDAC10 CRISPR Activation Plasmid (h)sc-403221-ACThumanGene ActivationNEWNot Yet Rated
HDAC2 CRISPR Activation Plasmid (m)sc-420817-ACTmouseGene ActivationNEWNot Yet Rated
HDAC3 CRISPR Activation Plasmid (m)sc-420818-ACTmouseGene ActivationNEWNot Yet Rated
HDAC5 CRISPR Activation Plasmid (m)sc-420819-ACTmouseGene ActivationNEWNot Yet Rated
HDAC6 CRISPR Activation Plasmid (m)sc-420820-ACTmouseGene ActivationNEWNot Yet Rated
HDAC7 CRISPR Activation Plasmid (m)sc-425052-ACTmouseGene ActivationNEWNot Yet Rated
HDAC8 CRISPR Activation Plasmid (m)sc-427666-ACTmouseGene ActivationNEWNot Yet Rated
HDAC9 CRISPR Activation Plasmid (m)sc-429766-ACTmouseGene ActivationNEWNot Yet Rated
HDAC10 CRISPR Activation Plasmid (m)sc-431327-ACTmouseGene ActivationNEWNot Yet Rated
HDAC4 CRISPR Activation Plasmid (m)sc-431586-ACTmouseGene ActivationNEWNot Yet Rated
HDAC11 CRISPR Activation Plasmid (m)sc-433149-ACTmouseGene ActivationNEWNot Yet Rated
HDAC1 CRISPR Activation Plasmid (m)sc-436647-ACTmouseGene ActivationNEWNot Yet Rated

HDAC siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

PRODUCT NAMECAT. #SPECIESAPPLICATIONSCITATIONSRATING
HDAC1 siRNA (h)sc-29343humanGene Silencing5
HDAC1 shRNA Plasmid (h)sc-29343-SHhumanGene Silencing
HDAC1 shRNA (h) Lentiviral Particlessc-29343-VhumanGene Silencing
HDAC1 siRNA (m)sc-29344mouseGene Silencing1
HDAC1 shRNA Plasmid (m)sc-29344-SHmouseGene Silencing
HDAC1 shRNA (m) Lentiviral Particlessc-29344-VmouseGene Silencing
HDAC2 siRNA (h)sc-29345humanGene Silencing3
HDAC2 shRNA Plasmid (h)sc-29345-SHhumanGene Silencing
HDAC2 shRNA (h) Lentiviral Particlessc-29345-VhumanGene Silencing
HDAC2 siRNA (m)sc-29346mouseGene Silencing
HDAC2 shRNA Plasmid (m)sc-29346-SHmouseGene Silencing
HDAC2 shRNA (m) Lentiviral Particlessc-29346-VmouseGene Silencing
HDAC3 siRNA (h)sc-35538humanGene Silencing6
HDAC3 shRNA Plasmid (h)sc-35538-SHhumanGene Silencing
HDAC3 shRNA (h) Lentiviral Particlessc-35538-VhumanGene Silencing
HDAC3 siRNA (m)sc-35539mouseGene Silencing
HDAC3 shRNA Plasmid (m)sc-35539-SHmouseGene Silencing
HDAC3 shRNA (m) Lentiviral Particlessc-35539-VmouseGene Silencing
HDAC4 siRNA (h)sc-35540humanGene Silencing2
HDAC4 shRNA Plasmid (h)sc-35540-SHhumanGene Silencing
HDAC4 shRNA (h) Lentiviral Particlessc-35540-VhumanGene Silencing
HDAC4 siRNA (m)sc-35541mouseGene Silencing1
HDAC4 shRNA Plasmid (m)sc-35541-SHmouseGene Silencing
HDAC4 shRNA (m) Lentiviral Particlessc-35541-VmouseGene Silencing
HDAC5 siRNA (h)sc-35542humanGene Silencing
HDAC5 shRNA Plasmid (h)sc-35542-SHhumanGene Silencing
HDAC5 shRNA (h) Lentiviral Particlessc-35542-VhumanGene Silencing
HDAC5 siRNA (m)sc-35543mouseGene Silencing1
HDAC5 shRNA Plasmid (m)sc-35543-SHmouseGene Silencing1
HDAC5 shRNA (m) Lentiviral Particlessc-35543-VmouseGene Silencing
HDAC6 siRNA (h)sc-35544humanGene Silencing4
HDAC6 shRNA Plasmid (h)sc-35544-SHhumanGene Silencing
HDAC6 shRNA (h) Lentiviral Particlessc-35544-VhumanGene Silencing
HDAC6 siRNA (m)sc-35545mouseGene Silencing2
HDAC6 shRNA Plasmid (m)sc-35545-SHmouseGene Silencing
HDAC6 shRNA (m) Lentiviral Particlessc-35545-VmouseGene Silencing
HDAC7 siRNA (h)sc-35546humanGene Silencing
HDAC7 shRNA Plasmid (h)sc-35546-SHhumanGene Silencing
HDAC7 shRNA (h) Lentiviral Particlessc-35546-VhumanGene Silencing
HDAC7 siRNA (m)sc-35547mouseGene Silencing1
HDAC7 shRNA Plasmid (m)sc-35547-SHmouseGene Silencing
HDAC7 shRNA (m) Lentiviral Particlessc-35547-VmouseGene Silencing1
HDAC8 siRNA (h)sc-35548humanGene Silencing1
HDAC8 shRNA Plasmid (h)sc-35548-SHhumanGene Silencing
HDAC8 shRNA (h) Lentiviral Particlessc-35548-VhumanGene Silencing
HDAC8 siRNA (m)sc-35549mouseGene Silencing1
HDAC8 shRNA Plasmid (m)sc-35549-SHmouseGene Silencing
HDAC8 shRNA (m) Lentiviral Particlessc-35549-VmouseGene Silencing
HDAC9 siRNA (h)sc-35550humanGene Silencing1
HDAC9 shRNA Plasmid (h)sc-35550-SHhumanGene Silencing
HDAC9 shRNA (h) Lentiviral Particlessc-35550-VhumanGene Silencing
HDAC9 siRNA (m)sc-35551mouseGene Silencing1
HDAC9 shRNA Plasmid (m)sc-35551-SHmouseGene Silencing
HDAC9 shRNA (m) Lentiviral Particlessc-35551-VmouseGene Silencing
HDAC1 siRNA (h2)sc-44208humanGene Silencing
HDAC1 shRNA Plasmid (h2)sc-44208-SHhumanGene Silencing
HDAC1 shRNA (h2) Lentiviral Particlessc-44208-VhumanGene Silencing
HDAC2 siRNA (h2)sc-44262humanGene Silencing
HDAC2 shRNA Plasmid (h2)sc-44262-SHhumanGene Silencing
HDAC2 shRNA (h2) Lentiviral Particlessc-44262-VhumanGene Silencing
HDAC8 siRNA (h2)sc-44305humanGene SilencingNot Yet Rated
HDAC8 shRNA Plasmid (h2)sc-44305-SHhumanGene SilencingNot Yet Rated
HDAC8 shRNA (h2) Lentiviral Particlessc-44305-VhumanGene SilencingNot Yet Rated
HDAC10 siRNA (h)sc-72307humanGene Silencing
HDAC10 shRNA Plasmid (h)sc-72307-SHhumanGene Silencing
HDAC10 shRNA (h) Lentiviral Particlessc-72307-VhumanGene Silencing
HDAC10 siRNA (m)sc-72308mouseGene SilencingNot Yet Rated
HDAC10 shRNA Plasmid (m)sc-72308-SHmouseGene SilencingNot Yet Rated
HDAC10 shRNA (m) Lentiviral Particlessc-72308-VmouseGene SilencingNot Yet Rated
HDAC11 siRNA (h)sc-106896humanGene Silencing
HDAC11 shRNA Plasmid (h)sc-106896-SHhumanGene Silencing
HDAC11 shRNA (h) Lentiviral Particlessc-106896-VhumanGene Silencing
HDAC11 siRNA (m)sc-145909mouseGene Silencing
HDAC11 shRNA Plasmid (m)sc-145909-SHmouseGene Silencing
HDAC11 shRNA (m) Lentiviral Particlessc-145909-VmouseGene Silencing
HDAC11 siRNA (r)sc-156104ratGene SilencingNot Yet Rated
HDAC11 shRNA Plasmid (r)sc-156104-SHratGene SilencingNot Yet Rated
HDAC11 shRNA (r) Lentiviral Particlessc-156104-VratGene SilencingNot Yet Rated
HDAC1 siRNA (r)sc-270070ratGene Silencing
HDAC1 shRNA Plasmid (r)sc-270070-SHratGene Silencing
HDAC1 shRNA (r) Lentiviral Particlessc-270070-VratGene Silencing
HDAC2 siRNA (r)sc-270150ratGene SilencingNot Yet Rated
HDAC2 shRNA Plasmid (r)sc-270150-SHratGene SilencingNot Yet Rated
HDAC2 shRNA (r) Lentiviral Particlessc-270150-VratGene SilencingNot Yet Rated
HDAC3 siRNA (r)sc-270161ratGene Silencing1
HDAC3 shRNA Plasmid (r)sc-270161-SHratGene Silencing
HDAC3 shRNA (r) Lentiviral Particlessc-270161-VratGene Silencing

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. There are several members of the histone deacetylases family.