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FCP1 AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of FCP1 antibodies. Select FCP1 antibodies from several monoclonal and/or polyclonal FCP1 antibodies listed below. View detailed FCP1 antibody specifications by linking to the specific product blocks. Select appropriate FCP1 antibodies for your research by isotype, epitope, applications and species reactivity. FCP1 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of FCP1 Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional FCP1 Antibodies including, FCP1a, FCP1b
FCP1 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
RNA polymerase II (RNAP II) comprises a 12 subunit protein complex that mediates transcription. RNAP II contains a unique carboxy terminal domain (CTD), which consists of 52 repeats of the consensus heptapeptide Tyr-Ser-Pro-Thr-Ser-Pro-Ser. The RNAP II isoform with an unphosphorylated CTD associates with transcription initiation complexes, whereas the isoform with a phosphorylated CTD is involved in transcription elongation. FCP1, also designated TFIIF-associated CTD phosphatase, is a protein phosphatase dedicated to the CTD of RNAP II that mediates the recycling of RNAP II during the transcription cycle. FCP1 specifically targets phosphorylated CTD serine 2 and 5 with similar affinities. Phosphorylation of FCP1 itself is necessary for sufficient activity of the protein and its interaction with TFIIF. Upon activation, the α-helical carboxy terminus of FCP1 binds to RAP74 to form a complex. FCP1 also represses HIV-1 Tat-mediated transactivation, and, therefore, may represent a specific target for modulation of Tat activity in infected cells. |
