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FAK AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of FAK antibodies. Select FAK antibodies from several monoclonal and/or polyclonal FAK antibodies listed below. View detailed FAK antibody specifications by linking to the specific product blocks. Select appropriate FAK antibodies for your research by isotype, epitope, applications and species reactivity. FAK gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of FAK Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.See FAK Inhibitors or FAK Activators for functional analysis of cellular responses to FAK.
Phospho-Specific FAK Antibodies
FAK siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
Focal adhesion kinase was initially identified as a major substrate for the intrinsic protein tyrosine kinase activity of Src encoded pp60. The deduced amino acid sequence of FAK p125 has shown it to be a cytoplasmic protein tyrosine kinase whose sequence and structural organization are unique as compared to other proteins described to date. Localization of p125 by immunofluorescence suggests that it is primarily found in cellular focal adhesions leading to its designation as focal adhesion kinase (FAK). FAK is concentrated at the basal edge of only those basal keratinocytes that are actively migrating and rapidly proliferating in repairing burn wounds and is activated and localized to the focal adhesions of spreading keratinocytes in culture. Thus, it has been postulated that FAK may have an important in vivo role in the reepithelialization of human wounds. FAK protein tyrosine kinase activity has also been shown to increase in cells stimulated to grow by use of mitogenic neuropeptides or neurotransmitters acting through G protein coupled receptors. |
