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EPHEXIN AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of EPHEXIN antibodies. Select EPHEXIN antibodies from several monoclonal and/or polyclonal EPHEXIN antibodies listed below. View detailed EPHEXIN antibody specifications by linking to the specific product blocks. Select appropriate EPHEXIN antibodies for your research by isotype, epitope, applications and species reactivity. EPHEXIN gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of EPHEXIN Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
EPHEXIN siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
EPHEXIN, also known as NGEF (neuronal guanine nucleotide exchange factor), is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species. |
