Welcome to Santa Cruz Biotechnology!

EDG-5 Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of EDG-5 antibodies. Select EDG-5 antibodies from several monoclonal and/or polyclonal EDG-5 antibodies listed below. View detailed EDG-5 antibody specifications by linking to the specific product blocks. Select appropriate EDG-5 antibodies for your research by isotype, epitope, applications and species reactivity. EDG-5 gene silencer products in siRNA, shRNA Plasmid, shRNA Lentiviral Particle and CRISPR/Cas9 Knockout Plasmid formats are also available as well as CRISPR/dCas9 Activation Plasmids for gene activation.

Introducing HOVERcruz™,

a unique system for rapid identification of EDG-5 Antibodies. Hover over product names in the table to see representative data for each product.

Live chat is now available! (click here)

Our live chat system is available to answer your product and ordering questions.

See chemical EDG-5 Inhibitors or chemical EDG-5 Activators for functional analysis of cellular responses to EDG-5.

EDG-5 (E-12)sc-365963mouse IgG1284-347 (h)WB, IP, IF, ELISAm, h
EDG-5 (F-3)sc-365589mouse IgG2a284-347 (h)WB, IP, IF, ELISAhuman
EDG-5 (C-16)sc-16085goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, c, b, p1
EDG-5 (H-18)sc-31577goat IgGcytoplasmic (h)WB, IP, IF, ELISAm, r, h, e, c, b, p
EDG-5 (H-64)sc-25491rabbit IgG284-347 (h)WB, IP, IF, ELISAm, r, h, b, p5

EDG-5 CRISPR Plasmids include:

Knockout PlasmidsHDR PlasmidsActivation PlasmidsCITATIONSRATING
EDG-5 CRISPR/Cas9 KO Plasmid (h):
EDG-5 HDR Plasmid (h):
EDG-5 Activation Plasmid (h):
NEWNot Yet Rated
EDG-5 CRISPR/Cas9 KO Plasmid (m):
EDG-5 HDR Plasmid (m):
EDG-5 Activation Plasmid (m):
NEWNot Yet Rated

EDG-5 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAsshRNA PlasmidsshRNA Lentiviral ParticlesCITATIONSRATING
EDG-5 siRNA (h): sc-39928EDG-5 shRNA Plasmid (h):
EDG-5 shRNA (h)
Lentiviral Particles: sc-39928-V
EDG-5 siRNA (m): sc-39929EDG-5 shRNA Plasmid (m):
EDG-5 shRNA (m)
Lentiviral Particles: sc-39929-V

The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through Gi/o proteins, which activate growth related pathways.