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EDG-5 Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of EDG-5 antibodies. Select EDG-5 antibodies from several monoclonal and/or polyclonal EDG-5 antibodies listed below. View detailed EDG-5 antibody specifications by linking to the specific product blocks. Select appropriate EDG-5 antibodies for your research by isotype, epitope, applications and species reactivity. EDG-5 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

Introducing HOVERcruz™,

a unique system for rapid identification of EDG-5 Antibodies. Hover over product names in the table to see representative data for each product.

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See EDG-5 Inhibitors or EDG-5 Activators for functional analysis of cellular responses to EDG-5.

PRODUCT NAMECAT. #ISOTYPEEPITOPEAPPLICATIONSSPECIESCITATIONSRATING
EDG-5 (E-12)sc-365963mouse IgG1284-347 (h)WB, IP, IF, ELISAm, hNEW
EDG-5 (F-3)sc-365589mouse IgG2a284-347 (h)WB, IP, IF, ELISAhumanNEW
EDG-5 (C-16)sc-16085goat IgGC-terminal (h)WB, IP, IF, ELISAm, r, h, c, b, p1
EDG-5 (H-18)sc-31577goat IgGcytoplasmic (h)WB, IP, IF, ELISAm, r, h, e, c, b, p
EDG-5 (H-64)sc-25491rabbit IgG284-347 (h)WB, IP, IF, ELISAm, r, h, b, p5

EDG-5 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAsshRNA PlasmidsshRNA Lentiviral ParticlesCITATIONSRANKING
EDG-5 siRNA (h): sc-39928EDG-5 shRNA Plasmid (h):
sc-39928-SH
EDG-5 shRNA (h)
Lentiviral Particles: sc-39928-V
EDG-5 siRNA (m): sc-39929EDG-5 shRNA Plasmid (m):
sc-39929-SH
EDG-5 shRNA (m)
Lentiviral Particles: sc-39929-V

The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. EDG-6, which is expressed in lymphoid and hematopoietic tissues and in lung, signals through Gi/o proteins, which activate growth related pathways.