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DERA AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of DERA antibodies. Select DERA antibodies from several monoclonal and/or polyclonal DERA antibodies listed below. View detailed DERA antibody specifications by linking to the specific product blocks. Select appropriate DERA antibodies for your research by isotype, epitope, applications and species reactivity. DERA gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of DERA Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
DERA siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
DERA (deoxyriboaldolase), also known as DEOC or CGI-26, is a 318 amino acid member of the deoC/fbaB aldolase protein family. Involved in the carbohydrate degradation pathway, DERA catalyzes the conversion of 2-deoxy-D-ribose 5-phosphate to D-glyceraldehyde 3-phosphate and an acetyldehyde. The gene that encodes DERA maps to human chromosome 12, which encodes over 1,100 genes within 132 million bases, making up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster, which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. |
