DEDD Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of DEDD antibodies. Select DEDD antibodies from several monoclonal and/or polyclonal DEDD antibodies listed below. View detailed DEDD antibody specifications by linking to the specific product blocks. Select appropriate DEDD antibodies for your research by isotype, epitope, applications and species reactivity. DEDD gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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Also see additional DEDD Antibodies including, DEDD2

Apoptosis is a physiological process by which multicellular organisms eliminate unwanted cells. DEDD (Death Effector Domain-containing DNA binding protein) induces apoptosis by triggering a series of intracellular protein-protein interactions mediated by the N-terminal DED motif. DEDD, a cytoplasmic protein, translocates to the nucleus during CD95-mediated apoptosis, where it localizes to nucleoli-like structures, activates caspase-6 and specifically inhibits RNA polymerase I-dependent transcription. The cell death activity of DEDD relates to its nuclear localization. The DED in DEDD is sufficient for its DNA binding, capspase-6 activating and Pol I specific transcriptional repressor activity. Point specific mutations indicate that the DED in DEDD represents a novel domain that is structually similar to other DEDs but functionally different from classical DEDs found in FADD or caspase-8. DEDD is widely expressed in a variety of tissues, with highest levels in the testis. The human DEDD gene maps to chromosome 1q23.3. Alternative splicing results in two transcript variants which encode the same protein.