DAP12 Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of DAP12 antibodies. Select DAP12 antibodies from several monoclonal and/or polyclonal DAP12 antibodies listed below. View detailed DAP12 antibody specifications by linking to the specific product blocks. Select appropriate DAP12 antibodies for your research by isotype, epitope, applications and species reactivity. DAP12 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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PRODUCT NAME	CAT. #	ISOTYPE	EPITOPE	APPLICATIONS	SPECIES	CITATIONS
DAP12 (A-20)	sc-7855	goat IgG	FL (m)	WB, IF, ELISA	m, r	5
DAP12 (A-4)	sc-166084	mouse IgG_2a	C-terminal (h)	WB, IP, IF, ELISA	m, r, h, c
DAP12 (A-8)	sc-166085	mouse IgG_2a	C-terminal (h)	WB, IP, IF, ELISA	m, r, h, c
DAP12 (FL-113)	sc-20783	rabbit IgG	1-113 (h)	WB, IP, IF, IHC(P), ELISA	h > m, r	6
DAP12 (C-20)	sc-7853	goat IgG	C-terminus (h)	WB, IP, IF, ELISA	m, r, h, c, b, p, e	3
DAP12 (G-5)	sc-133174	mouse IgG_2b	1-113 (h)	WB, IP, IF, ELISA	human
DAP12 (V-20)	sc-7854	goat IgG	central (h)	WB, IF, ELISA	h, b	1
DAP12 (B-2)	sc-166086	mouse IgG_2b	C-terminal (h)	WB, IP, IF, ELISA	m, r, h, c

DAP12 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:

siRNAs	shRNA Plasmids	shRNA Lentiviral Particles	CITATIONS	RANKING
DAP12 siRNA (h): sc-35172	DAP12 shRNA Plasmid (h): sc-35172-SH	DAP12 shRNA (h) Lentiviral Particles: sc-35172-V
DAP12 siRNA (m): sc-42854	DAP12 shRNA Plasmid (m): sc-42854-SH	DAP12 shRNA (m) Lentiviral Particles: sc-42854-V

Natural killer (NK) cells are regulated by stimulatory and inhibitory signals from a variety of receptors. Three main receptor families are responsible for NK cells recognition of MHC I molecules, including Ly-49, CD94/NKG2 and KIR (killer-cell inhibitory receptor). DAP12 is a phosphoprotein that is involved in the activation of NK cells. This protein interacts with membrane glycoproteins of the KIR family, resulting in cellular activation. DAP12 also binds to CD94/NKG2C, an activating NK cell receptor belonging to the C-type lectin superfamily. Additional proteins that bind to DAP12 include Ly-49D and Ly-49H, which associate with DAP12 in the plasma membrane. Phosphorylated DAP12 binds to ZAP-70 and Syk, suggesting that the activation pathway may be similar to that of the T and B cell antigen receptors.