CLC Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of CLC antibodies. Select CLC antibodies from several monoclonal and/or polyclonal CLC antibodies listed below. View detailed CLC antibody specifications by linking to the specific product blocks. Select appropriate CLC antibodies for your research by isotype, epitope, applications and species reactivity. CLC gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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Also see additional CLC Antibodies including, CLC-1, CLC-2, CLC-3, CLC-3 4 5, CLC-4, CLC-5, CLC-6... See More, CLC-7, CLC-K, CLC-KA, CLC-KB

The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. Mutations in the gene encoding CLC-1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC-2 is highly expressed in the epithelia of several organs including lung, which suggests CLC-2 may be apossible therapeutic target for cystic fibrosis. CLC-3 expression is particularly abundant in neuronal tissue, while CLC-4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC-5 lead to Dent’s disease, a renal disorder characterized by proteinuria and hypercalciuria. CLC-6 and CLC-7 are broadly expressed in several tissues including testes, kidney, brain and muscle. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascendin limb of the Henle loop in the inner medulla while CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments.