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CD45 AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of CD45 antibodies. Select CD45 antibodies from several monoclonal and/or polyclonal CD45 antibodies listed below. View detailed CD45 antibody specifications by linking to the specific product blocks. Select appropriate CD45 antibodies for your research by isotype, epitope, applications and species reactivity. CD45 gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of CD45 Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.See CD45 Inhibitors for functional analysis of cellular responses to CD45. Also see additional CD45 Antibodies including, CD45R, CD45RA, CD45RB, CD45RC, CD45RO
Phospho-Specific CD45 Antibodies
CD45 siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
CD45 has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45 are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5 and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45, while the intracellular domain is conserved. CD45 functions as a phosphotyrosine phosphatase, a vital component for efficient tyrosine phosphorylation induction by the TCR/CD3 complex. The tyrosine phosphatase activity of CD45 is contained within the conserved intracellular domain. Src and Syk family protein tyrosine kinases are utilized by the TCR/CD3 complex to initiate signaling cascades. Several members of these two families, including Lck, Fyn and ZAP-70, have been implicated as physiological substrates of CD45. |
