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BECN AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of BECN antibodies. Select BECN antibodies from several monoclonal and/or polyclonal BECN antibodies listed below. View detailed BECN antibody specifications by linking to the specific product blocks. Select appropriate BECN antibodies for your research by isotype, epitope, applications and species reactivity. BECN gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of BECN Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.Also see additional BECN Antibodies including, BECN1, BECN1L1
BECN siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
BECN1 (Beclin 1) is a coiled-coil protein that has been implicated as an inhibitor of tumorigenesis. BECN1, which associates with Bcl-2, plays a significant role in autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Autophagy is controlled by the same signal transduction pathway that induces the phosphorylation of the Ribosomal Protein S6, and both are mediated via amino acids. BECN1 expression in various carcinoma cell lines such as MCF7 is low, whereas it is ubiquitously expressed in normal breast tissue. In transfected MCF7 cells, BECN1 complements autophagocytosis and, subsequently, inhibits cellular proliferation. Additionally, BECN1 shares structural similarity to the yeast autophagy gene product, Apg6, and was one of the first mammalian proteins discovered to mediate autophagy. |
