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Bax AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of Bax antibodies. Select Bax antibodies from several monoclonal and/or polyclonal Bax antibodies listed below. View detailed Bax antibody specifications by linking to the specific product blocks. Select appropriate Bax antibodies for your research by isotype, epitope, applications and species reactivity. Bax gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of Bax Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.See Bax Activators for functional analysis of cellular responses to Bax. Also see additional Bax Antibodies including, Bax beta
Bax siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
The Bax protein belongs to a growing family of related Bcl-2 proteins which regulate apoptosis by controlling the permeability of the mitochondrial membrane to the apoptogenic protein cytochrome c. Cytochrome c, in turn, activates the proteolytic proteins known as caspases. The Bcl-2 protein family members play both pro-apoptotic and anti-apoptotic roles, and all possess at least one of four conserved motifs known as "Bcl-2 homology domains" (BH1 to BH4). These domains play key roles as binding sites which allow these proteins to form homodimers or heterodimers, thus regulating the apoptotic activity of these proteins. Bax is a cytosolic protein that plays a pro-apoptotic role by binding to the permeability transition pore complex (PTPC) and by binding Bcl-2, a protein which plays an anti-apoptotic role. The ratio between Bax/Bcl-2 heterodimers and Bax/Bax homodimers appears to be pivotal in determining the lifespan of a cell. Bax exhibits numerous splice variants, including α, β, δ, γ and κ. Bax-β is a 218 amino acid protein. Intron 5 of Bax-beta RNA consists of 630 bp and does not undergo splicing, which accounts for the apparent size increase. |
