APPBP Antibodies

Santa Cruz Biotechnology, Inc. offers a broad range of APPBP antibodies. Select APPBP antibodies from several monoclonal and/or polyclonal APPBP antibodies listed below. View detailed APPBP antibody specifications by linking to the specific product blocks. Select appropriate APPBP antibodies for your research by isotype, epitope, applications and species reactivity. APPBP gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available.

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Also see additional APPBP Antibodies including, APPBP1, APPBP2

APPBP1 (β-Amyloid precursor protein-binding protein 1), also known as NAE1 (NEDD8-activating enzyme E1 regulatory subunit 1), HPP1 or ula-1, is a member of the ubiquitin-activating E1 family. In fetal tissues APPBP1 is widely expressed and in adult tissues it is expressed throughout the brain. APPBP1 is a cell membrane associated protein and functions as the regulatory subunit in a heterodimer with UBA3. The APPBP1/UBA3 complex binds to and activates NEDD8, a ubiquitin-like protein involved in signal transduction, cell proliferation and development. This suggests that APPBP1 affects a variety of cellular functions. APPBP2 (β-Amyloid precursor protein-binding protein2), also known as protein interacting with APP tail 1 (PAT1) or Ara67, is a hydrophilic, microtubule binding protein that functions in the trafficking of β-Amyloid precursor protein. It is expressed in a variety of cell types and localizes to the cytoplasm. APPBP2 shares homology with kinesin light chain. It consists of a coiled-coil domain, PKC phosphorylation sites, four imperfect C-terminal tandem repeats, eight tetratricopeptide repeats and N- and C-terminal globular structures.