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Anamorsin AntibodiesSanta Cruz Biotechnology, Inc. offers a broad range of Anamorsin antibodies. Select Anamorsin antibodies from several monoclonal and/or polyclonal Anamorsin antibodies listed below. View detailed Anamorsin antibody specifications by linking to the specific product blocks. Select appropriate Anamorsin antibodies for your research by isotype, epitope, applications and species reactivity. Anamorsin gene silencer products in siRNA, shRNA Plasmid and shRNA Lentiviral Particle formats are also available. Introducing HOVERcruz™,a unique system for rapid identification of Anamorsin Antibodies. Hover over product names in the table to see representative data for each product.Live chat is now available! (click here)Our live chat system is available to answer your product and ordering questions.
Anamorsin siRNA, shRNA Plasmid and shRNA Lentiviral Particles gene silencers include:
The name of the protein Anamorsin, also designated cytokine-induced apoptosis inhibitor 1 (CIAPIN1), comes from the Latin term “ana-mors-in”, meaning “anti-death molecule”. During hematopoiesis, Anamorsin is crucial for mediating the anti-apoptotic effects of various cytokines. It is a ubiquitously expressed protein, and when it is overexpressed, it confers apoptotic resistance. Anamorsin is primarily expressed in the cytoplasm of liver, pancreas and heart tissue cells and does not show any homology to known apoptosis regulatory molecules of the Bcl-2 or CASP families, or to signal transduction molecules. Anamorsin expression in mouse cells confers resistance to apoptosis caused by IL-3 (interleukin-3) deprivation. Studies demonstrate that the addition of growth factors, such as EPO (erythropoietin), SCF (stem cell factor), TPO (thrombopoietin) or IL-3, all of which depend on RAS signaling, induce dose-dependent expression of Anamorsin in mouse cells. |
