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Protease Inhibitors

PRODUCT	CATALOG #	DESCRIPTION	AMOUNT
2-Guanidinoethylmercaptosuccinic Acid	sc-203769	2-Guanidinoethylmercaptosuccinic Acid, also knowns as GEMSA, is a potent inhibitor of enkephalin convertase, known as a carboxypeptidase B-like processing enzyme.	5 mg
a-Iodoacetamide	sc-203320	An electrophile used for covalent modification of cysteine, methionine, and histidine protein residues.	25 g
Acetyl-Pepstatin	sc-203802	Aspartyl protease inhibitor that acts as an effective inhibitor of HIV-1 proteinase (K_i = 20 nM at pH 4.7) and HIV-2 proteinase (K_i = 5 nM at pH 4.7).	1 mg
Antipain	sc-291906	A reversible inhibitor of Ser and Cys proteases with an activity spectrum comparable to leupeptin. H-1765 inhibited transformation of NIH3T3 cells after transfection with an activated H-ras oncogene. Has been employed for evaluating the role of proteases in the process of malignant transformation of BALB/c 3T3 cells.	5 mg/25 mg
Aprotinin	sc-3595	Reversible inhibitor of esterase and serine protease activity such as trypsin, chymotrypsin, kallikrein, plasmin, urokinase, and leukocyte protease.	10 mg/100 mg
bADA	sc-202967	Shown to be an irreversible cysteine protease inhibitor that contains aziridine-2,3-dicarboxylic acid as a reactive agent. Also been reported to be active against plasmodial and lysosomal cysteine proteases.	2 mg
Benzamidine, Hydrochloride	sc-202973	Inhibitor of serine protease enzymes.	5 g/25 g
Butabindide oxalate	sc-361130	Butabindide oxalate is a selective and potent inhibitor of tripeptidyl peptidase II.	10 mg/50 mg
Camostat mesylate	sc-203867	Reported to be a protease and Trypsin inhibitor. Also shown to suppress spinal Fos expression in the rat and have direct regulatory effects on ductular cells of the dog pancreas.	10 mg/50 mg
Cilastatin sodium	sc-201312	A specific inhibitor of DPEP1, leukotriene D4 hydrolase and bacterial metallo-beta-lactamase. Exhibits nephroprotective effects in cyclosporine A-induced nephrotoxicity and is commonly used in conjunction with the antibiotic Imipenem (sc-205350).	10 mg/50 mg
Complete™ Protease Inhibitor Cocktail Tablet, EDTA-free	sc-29131	EDTA-free mixture of several protease inhibitors that inhibit cysteine and serine, but not metalloproteases.	20 tablets
Complete™ Protease Inhibitor Cocktail Tablet	sc-29130	Mixture of several protease inhibitors with broad inhibitory specificity. Useful for inhibition of serine, cysteine, and metalloproteases.	20 tablets
Diisopropylfluorophosphate	sc-203922	Serine protease inhibitor. Irreversible inactivator of acetylcholinesterase that can cross the blood-brain barrier. Selectively blocks T cell receptor-triggered programmed cell death in murine T cell hybridoma and in activated peripheral T cells.	1 g
e-Amino-n-caproic Acid	sc-202146	An antifibrinolytic agent which inhibits streptokinase and basic carboxypeptidases, but has been shown to enhance activation of urinary-type and tissue-type plasminogen.	500 g
Ebelactone B	sc-200826	Effective pancreatic lipase inhibitor derived from Streptomyces aburaviensis. Also inhibits hydrolysis of bradykinin and angiotensin (angiotensin I) through serine carboxypeptidase Y-like enzymes.	1 mg
Ecotin, E. coli	sc-221575	A strong broad range inhibitor of serine proteases. Exhibits picomolar binding constant for the inhibition of chymotrypsin, elastase, Factor Xa, Factor XIIa, kallikrein, and trypsin. Also acts as an effective inhibitor of collagenase. Exhibits biological activity by binding trypsin in the picomolar range.	100 µg
Epiamastatin hydrochloride	sc-214965	A metallo-protease inhibitor with selectivity for aminopeptidases.	5 mg
Iodoacetic Acid, Sodium Salt	sc-204014	A reagent shown to be used to modify cysteine residues in proteins to ultimately inhibit cysteine proteases.	25 g
L-1-Tosylamide-2-phenylethylchloromethyl Ketone	sc-295238	This product inhibits protease, and inactivates chymotrypsin but does not inactivate trypsin. It has been shown to irreversibly inhibit chymotrypsin-like serine proteases including ficin, bromelain, and papain. It has also been shown to inhibits I kappaB alpha-protease. Inhibition of I kappaB alpha-protease blocks the LPS- or cytokine-induced activation of nuclear factor kappaB (NF-kappaB), which then blocks iNOS induction and COX-2 transcription. It is reported to block apoptosis cell lines through the inhibition of the processing of caspases in some cell lines and to some stimuli. It can also be used in histone isolation.	100 mg/250 mg
Leupeptin hydrochloride	sc-215242	Produced by Actinomycetes and act as calpain, cysteine, and protease inhibitors. Studies show that Leupeptin preserves cardiac nitric oxide synthase 3 (NOS3).	5 mg/25 mg
Mezerein	sc-202707	Protein kinase C (PKC) activator. Second stage tumor promoter whereas phorbol-12-myristate 13-acetate (PMA) is a first stage tumor promoter. May be of use for studying phorbol ester receptor isotypes. Induces interleukin-1α. Coinducer of interferon with phytohemagglutinin.	1 mg
Nafamostat mesylate	sc-201307	A highly effective tryptase (K_i=95.3 pM) inhibitor that can promote synthesis of interferon-gamma, tumor necrosis factor-alpha, IL-12, and IL-18.	10 mg/50 mg
Omi/HtrA2 Protease Inhibitor, Ucf-101	sc-222101		10 mg
p-APMSF, Hydrochloride	sc-204155	An irreversible and specific protease inhibitor that blocks intracellular acidification, DNA fragmentation, and 5-Fluoro-2'-deoxyuridine induced cell death.	5 mg
PF-356231	sc-222151		1 mg/5 mg
Phosphoramidon	sc-201283	An inhibitor of the metalloprotease NEP and its homologue NEP2, which both belong to a group of type II integral membrane glycoproteins.	5 mg/25 mg
PPACK II, Trifluoroacetate Salt	sc-203215	A potent, specific and irreversible inhibitor of glandular and plasma kallikreins. Inhibits rat adrenal kininogenase and inactivates native human hageman factor.	10 mg
Propionyl-leupeptin hemisulfate salt	sc-264149	Inhibits cysteine and serine proteases.	25 mg/100 mg
Thiorphan (DL)	sc-201287	An enkephalinase and metalloproteinase inhibitor that shows antinociceptive activity. Displays antiapoptotic and proliferative protective effects.	5 mg/25 mg
TLCK hydrochloride	sc-201296	Irreversibly inhibits trypsin-like serine proteases such as granzyme D. Inhibits LPS-induced expression of COX-2 in macrophages and the chymotrypsin- and trypsin-like activity of the proteasome.	200 mg
TPCK	sc-201297	A potent serine and cysteine protease inhibitor, disables NF-κB activation and subsequently shuts down COX-2 activity.	1 g
Trypsin Inhibitor, Corn	sc-204358	Specific, reversible inhibitor of trypsin. Also inhibits human Factor XIIa. May function in host resistance against fungal pathogens in crops.	1 mg
(Z-LL)2 Ketone	sc-311559	A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide.	5 mg
High quality protease inhibitors are provided as individual inhibitors and as cocktails to effectively protect proteins from a broad range of unwanted protease activity including serine, cysteine, and metelloproteases. One unit of activity is defined as the amount of enzyme that converts 1 µmol of substrate to product in one minute under the given assay conditions. Complete Protease Inhibitor Cocktail Tablet and Complete Protease Inhibitor Cocktail Tablet, EDTA-free are trademarks of Roche Applied Science.