ZDHHC8 Background Information Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZDHHC8 (zinc finger, DHHC-type containing 8), also known as KIAA1292, ZDHHCL1 or ZNF378 (zinc finger protein 378), is a 765 amino acid multi-pass membrane protein that localizes to the membrane of cytoplasmic vesicles and contains one DHHC-type zinc finger. Expressed as multiple alternatively spliced isoforms, ZDHHC8 functions as a putative palmitoyltransferase that catalyzes the conversion of palmitoyl-CoA and a protein-cysteine to an S-palmitoyl protein and free CoA, a reaction that is important in glutamatergic transmission. Defects in the gene encoding ZDHHC8 may be associated with an increased susceptibility to schizophrenia.
ZDHHC8 (S-14)
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ZDNNC8 (C-15): sc-86947. Western blot analysis of ZDNNC8 expression in KNRK (A) and LADMAC (B) whole cell lysates and mouse brain tissue extract (C).
ZDHHC8 (S-14): sc-86947. Western blot analysis of ZDHHC8 expression in WI 38 whole cell lysate.
ZDHHC8 (S-14): sc-86947. Western blot analysis of ZDHHC8 expression in LADMAC whole cell lysate (A) and mouse liver tissue extract (B).
ZDHHC8 (S-14): sc-86947. Western blot analysis of ZDHHC8 expression in non-transfected: sc-117752 (A) and human ZDHHC8 transfected: sc-116485 (B) 293T whole cell lysates.
