epitope mapping near the C-terminus of WDFY2 of human origin
recommended for detection of WDFY2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and avian
WDFY2 Background Information WD repeat and FYVE domain-containing protein 2 (WDFY2), also known as WDF2 and ZFYVE22, is a 400 amino acid protein that localizes to a set of small endosomes that are found within 100 nm from the plasma membrane. Highly conserved between species, WDFY2 consists of one FYVE-type zinc finger and seven WD repeats. The FYVE domain is a cysteine-rich domain of about 70 amino acids. Its primary role is to target signal-transducing proteins to cell membranes through binding to the membrane lipid phosphatidylinositol-3-phosphate with high specificity. WD-repeats are generally found in clusters of seven. They have no intrinsic catalytic activity, but they serve as a platform for protein-protein interactions. WDFY2 is suspected to play a critical role in the endocytic pathway.
WDFY2 (C-20)
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WDFY2 (C-20): sc-84658. Western blot analysis of WDFY2 expression in non-transfected: sc-117752 (A) and human WDFY2 transfected: sc-371325 (B) 293T whole cell lysates.
