Rab 8A Antibody (63-BJ): sc-81909

Rab 8A Antibody (63-BJ) is a mouse monoclonal IgG1 kappa light chain antibody that detects Rab 8A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Rab 8A antibody (63-BJ) is available as a non-conjugated format. Rab 8A protein plays a crucial role in intracellular transport, particularly in vesicle movement between the endoplasmic reticulum and Golgi apparatus, which is essential for proper protein secretion. Rab 8A protein localizes primarily in the cytoplasm and regulates vesicle trafficking, ensuring proteins reach correct destinations within cells. Rab 8A′s importance in maintaining cellular function stems from involvement in both endocytosis and exocytosis processes, vital for nutrient uptake and waste removal. Rab 8A interacts with various effector proteins that facilitate docking and fusion of transport vesicles with target membranes, highlighting an integral role in cellular transport machinery. With functionality across multiple species and applications, Rab 8A monoclonal antibody (63-BJ) serves as an invaluable tool for researchers studying protein transport dynamics and cellular function mechanisms.

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Rab 8A Antibody (63-BJ) References:

1. GTP-binding proteins in intracellular transport.  |  Pfeffer, SR. 1992. Trends Cell Biol. 2: 41-6. PMID: 14731525
2. The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.  |  Chavrier, P., et al. 1992. Gene. 112: 261-4. PMID: 1555775
3. Cloning of a Rab3 isotype predominantly expressed in adipocytes.  |  Baldini, G., et al. 1992. Proc Natl Acad Sci U S A. 89: 5049-52. PMID: 1594612
4. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.  |  Zahraoui, A., et al. 1989. J Biol Chem. 264: 12394-401. PMID: 2501306
5. Rab8a as a mitochondrial receptor for lipid droplets in skeletal muscle.  |  Ouyang, Q., et al. 2023. Dev Cell. 58: 289-305.e6. PMID: 36800997
6. The LRRK2 kinase substrates RAB8a and RAB10 contribute complementary but distinct disease-relevant phenotypes in human neurons.  |  Mamais, A., et al. 2024. Stem Cell Reports. 19: 163-173. PMID: 38307024
7. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag.  |  Chen, YT., et al. 1993. Proc Natl Acad Sci U S A. 90: 6508-12. PMID: 7688123
8. Coatomers and SNAREs in promoting membrane traffic.  |  Takizawa, PA. and Malhotra, V. 1993. Cell. 75: 593-6. PMID: 8242734
9. Friends and family: the role of the Rab GTPases in vesicular traffic.  |  Novick, P. and Brennwald, P. 1993. Cell. 75: 597-601. PMID: 8242735
10. The role of GTP-binding proteins in transport along the exocytic pathway.  |  Ferro-Novick, S. and Novick, P. 1993. Annu Rev Cell Biol. 9: 575-99. PMID: 8280472
11. Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation.  |  Torti, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 7553-7. PMID: 8356055
12. Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins.  |  Karniguian, A., et al. 1993. Proc Natl Acad Sci U S A. 90: 7647-51. PMID: 8356066

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rab 8A Antibody (63-BJ) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Rab 8A Antibody (63-BJ) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rab 8A Antibody (63-BJ) Specifications

Alternate Product Name: Rab 8A

Product Clone Name: 63-BJ

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 108-207

Epitope Target: Rab 8A

Epitope Species: human

Product Reactivity/Detection: Rab 8A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Rab 8A Antibody (63-BJ): N/A