Dmp1 Background Information The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy terminus of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate. A second member of the Myb proto-oncogene family, B-Myb, encodes another sequence-specific DNA binding protein. Studies suggest that B-Myb expression rescues cells from p53-induced G1 arrest mediated by p21. Dmp1 (also designated cyclin D binding myb-like transcription factor 1) has also been identified as a Myb-like transcription factor. It contains three tandem Myb repeats and has been shown to be a substrate for cyclin D-dependent kinases.
Dmp1 (DMTF5I250)
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Dmp1 (DMTF5I250): sc-81249 Western Blot analysis of human recombinant Dmp1 fusion protein.
