p-p38 MAPK Antibody (D-8): sc-7973

p-p38 MAPK Antibody (D-8) is a mouse monoclonal IgM antibody that detects Tyr 182 phosphorylated p38 alpha MAPK14, p38 beta MAPK11, and p38 gamma MAPK12 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p-p38 MAPK (D-8) antibody is available in both conjugated and non-conjugated forms, providing flexibility for various experimental needs. p38 MAPK proteins play a crucial role in cellular responses to stress and inflammatory signals, acting as key regulators in pathways that control cell differentiation, apoptosis, and cytokine production. p38 MAPK proteins are primarily located in the cytoplasm but can translocate to the nucleus in response to specific stimuli, which is vital for mediating cellular responses. This translocation allows p38 MAPK proteins to influence gene expression and cellular behavior in response to environmental changes, making these proteins essential for maintaining cellular homeostasis and responding to stressors. p38 MAPK proteins undergo phosphorylation at both threonine and tyrosine residues, a modification critical for activation and subsequent signaling functions. p-p38 MAPK (D-8) antibody enables researchers to effectively study the activation state of these important kinases and their role in various biological processes, enhancing our understanding of their contributions to health and disease.

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p-p38 MAPK Antibody (D-8) References:

1. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.  |  Tamura, K., et al. 2000. Cell. 102: 221-31. PMID: 10943842
2. Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells.  |  Sudo, T., et al. 2002. Biochem Biophys Res Commun. 291: 838-43. PMID: 11866441
3. Cardiac expression and subcellular localization of the p38 mitogen-activated protein kinase member, stress-activated protein kinase-3 (SAPK3).  |  Court, NW., et al. 2002. J Mol Cell Cardiol. 34: 413-26. PMID: 11991731
4. Active mutants of the human p38alpha mitogen-activated protein kinase.  |  Diskin, R., et al. 2004. J Biol Chem. 279: 47040-9. PMID: 15284239
5. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.  |  Zohn, IE., et al. 2006. Cell. 125: 957-69. PMID: 16751104
6. Molecular cloning of human p38 MAP kinase.  |  Han, J., et al. 1995. Biochim Biophys Acta. 1265: 224-7. PMID: 7696354
7. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.  |  Lee, JC., et al. Nature. 372: 739-46. PMID: 7997261
8. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).  |  Jiang, Y., et al. 1996. J Biol Chem. 271: 17920-6. PMID: 8663524
9. The primary structure of p38 gamma: a new member of p38 group of MAP kinases.  |  Li, Z., et al. 1996. Biochem Biophys Res Commun. 228: 334-40. PMID: 8920915

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-p38 MAPK Antibody (D-8) has 571 citations in a variety of scientific publications.

Primary antibodies like Anti-p-p38 MAPK Antibody (D-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-p38 MAPK Antibody (D-8) Specifications

Alternate Product Name: p38 MAPK

Product Clone Name: D-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: Tyr 182

Epitope Target: p38 alpha MAPK14

Epitope Species: human

Product Reactivity/Detection: Tyr 182 phosphorylated p38 alpha MAPK14, p38 beta MAPK11 and p38 gamma MAPK12

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 571 citations in various scientific publications

Available Conjugates/Forms for p-p38 MAPK Antibody (D-8): AC: Agarose, FITC: Fluoroscein, P: Blocking Peptide, TRITC: Rhodamine

The preferred p-p38 MAPK antibody is p-p38 MAPK Antibody (E-1): sc-166182.