CD209b Antibody (ER-TR9): sc-73642

CD209b Antibody (ER-TR9) is a rat monoclonal IgM antibody that detects CD209b protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD209b (ER-TR9) antibody is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). CD209b protein plays a crucial role in the immune system as a cell adhesion receptor that facilitates the endocytosis and degradation of pathogens, thereby enhancing the immune response. CD209b is primarily expressed on dendritic cells, which are essential for capturing antigens in peripheral tissues and transporting them to lymphoid organs, a process that is vital for inducing T cell responses. CD209b interaction with specific pathogens not only aids in pathogen clearance but also influences the activation and differentiation of T cells, making CD209b a key player in bridging innate and adaptive immunity. The mouse CD209 family includes several other receptors, such as CD209a, which also contribute to immune surveillance and pathogen recognition, highlighting the importance of this protein family in maintaining immune homeostasis.

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CD209b Antibody (ER-TR9) References:

1. The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells.  |  Engering, A., et al. 2002. J Immunol. 168: 2118-26. PMID: 11859097
2. Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo.  |  Geijtenbeek, TB., et al. 2002. Blood. 100: 2908-16. PMID: 12351402
3. DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation.  |  Moris, A., et al. 2004. Blood. 103: 2648-54. PMID: 14576049
4. L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus.  |  Cormier, EG., et al. 2004. Proc Natl Acad Sci U S A. 101: 14067-72. PMID: 15371595
5. Sialylation of ICAM-2 on platelets impairs adhesion of leukocytes via LFA-1 and DC-SIGN.  |  Weber, KS., et al. 2004. Inflammation. 28: 177-88. PMID: 15673159
6. Lactoferrin prevents dendritic cell-mediated human immunodeficiency virus type 1 transmission by blocking the DC-SIGN--gp120 interaction.  |  Groot, F., et al. 2005. J Virol. 79: 3009-15. PMID: 15709021
7. Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation.  |  de la Rosa, G., et al. 2005. J Leukoc Biol. 77: 699-709. PMID: 15728245
8. A variant in the CD209 promoter is associated with severity of dengue disease.  |  Sakuntabhai, A., et al. 2005. Nat Genet. 37: 507-13. PMID: 15838506
9. The location of asparagine-linked glycans on West Nile virions controls their interactions with CD209 (dendritic cell-specific ICAM-3 grabbing nonintegrin).  |  Davis, CW., et al. 2006. J Biol Chem. 281: 37183-94. PMID: 17001080

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD209b Antibody (ER-TR9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CD209b Antibody (ER-TR9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD209b Antibody (ER-TR9) Specifications

Alternate Product Name: CD209b

Product Clone Name: ER-TR9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM

Amino Acids:

Epitope Target: CD209b

Epitope Species: mouse

Product Reactivity/Detection: CD209b, also designated SIGN-R1,

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgM in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CD209b Antibody (ER-TR9): FITC: Fluoroscein, L: Azide-Free, PE: Phycoerythrin