HACS1 Background Information HACS1 (hematopoietic adaptor containing SH3 and SAM domains 1) is a 373 amino acid protein encoded by the human gene SAMSN1. HACS1 is a family member of a novel group of putative adaptors and scaffold proteins containing SH3 and SAM (sterile a motif) domains. SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors and scaffold proteins. HACS1 is upregulated by IL-4, IL-13, anti-IgM, and anti-CD40 in human peripheral blood B cells. In murine spleen B cells, HACS1 can also be upregulated by lipopolysaccharide, but not IL-13. Induction of HACS1 by IL-4 is dependent on Stat6 signaling and can also be impaired by inhibitors of phosphatidylinositol 3-kinase, protein kinase C (PKC) and NFkB. HACS1 associates with tyrosine-phosphorylated proteins after B cell activation and binds in vitro to the inhibitory molecule paired Ig-like receptor B. HACS1 is preferentially expressed in normal hematopoietic tissues and malignancies, including myeloid leukemia, lymphoma and myeloma.
HACS1 (C-15)
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HACS1 (C-15): sc-66382. Western blot analysis of HACS1 expression in K-562 whole cell lysate.
HACS1 (C-15): sc-66382. Western blot analysis of HACS1 expression in non-transfected 293T: sc-117752 (A), human HACS1 transfected 293T: sc-113689 (B) and K-562 (C) whole cell lysates.
