p-Akt1 Antibody (104A282): sc-52940
- p-Akt1 Antibody (104A282) is a mouse monoclonal IgG1 κ, cited in 36 publications, provided at 50 µg/0.5 ml
- raised against synthetic p-Ak1 of human origin
- recommended for detection of Ser 473 phosphorylated Akt1 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-Akt1 Antibody (104A282). This work is in progress.
p-Akt1 Antibody (104A282) is a mouse monoclonal IgG1 antibody that detects p-Akt1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Akt1, a phosphorylated form of the serine/threonine kinase Akt1, plays a crucial role in various cellular processes, including metabolism, cell survival, and growth regulation. p-Akt1 is primarily located in the cytoplasm and translocates to the plasma membrane upon activation, which is essential for function in signaling pathways that mediate cellular responses to insulin and growth factors. In addition to plasma membrane localization, phosphorylated Akt1 can also be found in the nucleus, where p-Akt1 regulates transcription factors and nuclear proteins involved in cell cycle progression and DNA repair. p-Akt1′s subcellular distribution is tightly regulated by specific binding partners and scaffold proteins, ensuring precise signaling outcomes. Aberrant localization or misregulation of p-Akt1 can disrupt these pathways, contributing to pathological conditions such as uncontrolled cell proliferation. Proper localization of p-Akt1 is vital, as p-Akt1 allows for interaction with other signaling molecules, facilitating downstream effects that promote cell proliferation and survival. Dysregulation of p-Akt1 signaling has been implicated in numerous diseases, including cancer and metabolic disorders, making p-Akt1 a significant target for therapeutic intervention. Anti-p-Akt1 antibody (104A282) is an invaluable tool for researchers studying the Akt signaling pathway and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Akt1 Antibody (104A282) | sc-52940 | 50 µg/0.5 ml | $322.00 |