Layilin Background Information The actin cytoskeleton is crucial for cell shape and motility. The interactions between the cell membrane and actin filaments are important for many cellular processes. Layilin is a widely expressed integral membrane hyaluronan receptor that interacts with the ERM protein family of cytoskeletal membrane linker molecule members, including talin, ezrin, moesin, and radixin. Layilin plays an important role in cell adhesion and motility. Layilin is important for the maintenance of the cortical structure in the cell because it mediates signals from the extracellular matrix to the cytoskeleton. In spreading cells, Layilin acts as a membrane-binding site for talin in the peripheral ruffles, and it may play a role in the migration of cells to a wound site.
