epitope mapping within an internal region of PADI4 of human origin
recommended for detection of PADI4 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA; may cross-react with PADI1, PADI3 and PADI6
PADI4 Background Information The protein arginine deiminase (PAD) family of proteins are often referred to as peptidylarginine deiminases. They catalyze the deimination of arginine residues of proteins. In the presence of calcium, the proteins in the PAD family act as catalysts for the posttranslational modification reaction that converts methylarginine to citrulline. The PAD proteins are cytoplasmic proteins primarily detected in eosinophils and neutrophils. The gene encoding for PADI4 is believed to be a rheumatoid arthritis susceptibility locus. By increasing the citrullination of proteins in rheumatoid arthritis synovial tissues, it may play a role in the pathogenesis of the disease.
PADI4 (K-18)
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PADI4 (K-18): sc-47287. Western blot analysis of PADI4 expression in mouse PBL whole cell lysate.
PADI4 (K-18): sc-47287. Western blot analysis of PADI4 expression in non-transfected: sc-117752 (A) and human PADI4 transfected: sc-114204 (B) 293T whole cell lysates.
