Ajuba (C-13) Anticorpo: sc-46721

Ajuba Background Information
The LIM protein Ajuba (JUB), a member of the Zyxin family, mediates various cellular events. Ajuba is a component of the IL-1 signaling pathway modulating IL-1-induced NFkB activation by influencing the assembly and activity of the aPKC/p62/TRAF6 multiprotein signaling complex. Ajuba also plays a role in cadherin-mediated cell-cell adhesion and influences cell migration by regulating PI(4,5)P2 synthesis through direct activation of PIPKIa activity. Differentiating mouse embryonic stem cells show elevated Ajuba transcription. In adult mouse tissues, Ajuba is present in skin, brain and genitourinary organs. Immunofluorescence analysis of unsynchronized HeLa cells shows cytoplasmic staining. In cells synchronized at G2/M, Ajuba localizes to the centrosome, where it complexes with LATS2 to regulate the organization of the spindle apparatus through recruitment of g Tubulin.