Stat1 Antibody (C-136): sc-464
- Stat1 Antibody (C-136) is a mouse monoclonal IgG1 κ Stat1 antibody, cited in 194 publications, provided at 200 µg/ml
- epitope mapping between amino acids 613-739 of Stat1 of human origin
- Stat1 Antibody (C-136) is recommended for detection of Stat1 of mouse, rat and human origin by WB, IP and IF
- Anti-Stat1 Antibody (C-136) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-464 X, 200 µg/0.1 ml)
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Stat1 Antibody (C-136) for WB applications. This reagent is now offered in a bundle with Stat1 Antibody (C-136) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
Stat1 Antibody (C-136) is a mouse monoclonal IgG1 kappa light chain antibody that detects Stat1 protein of mouse, rat, and human origin through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Stat1 (C-136) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. Stat1 protein plays a crucial role in mediating cellular responses to interferons and other cytokines, which are vital for the immune response and regulation of gene expression. Upon activation by ligands such as interferons, Stat1 undergoes tyrosine phosphorylation, allowing formation of a heterodimer with Stat2, which is part of the ISGF3 transcription factor complex that translocates to the nucleus to initiate transcription of interferon-stimulated genes. This process is essential for the antiviral response and the regulation of immune functions, highlighting the importance of Stat1 in maintaining cellular homeostasis and responding to external stimuli.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Stat1 Antibody (C-136) References:
- STAT1 and pathogens, not a friendly relationship. | Najjar, I. and Fagard, R. 2010. Biochimie. 92: 425-44. PMID: 20159032
- Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation. | Imitola, J., et al. 2023. Front Cell Neurosci. 17: 1156802. PMID: 37663126
- The complementary roles of STAT3 and STAT1 in cancer biology: insights into tumor pathogenesis and therapeutic strategies. | Wang, W., et al. 2023. Front Immunol. 14: 1265818. PMID: 38022653
- Human STAT1 gain of function with chronic mucocutaneous candidiasis: A comprehensive review for strengthening the connection between bedside observations and laboratory research. | Asano, T., et al. 2024. Immunol Rev. 322: 81-97. PMID: 38084635
- Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3. | Qureshi, SA., et al. 1995. Proc Natl Acad Sci U S A. 92: 3829-33. PMID: 7537377
- Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3. | Schaefer, TS., et al. 1995. Proc Natl Acad Sci U S A. 92: 9097-101. PMID: 7568080
- Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. | Schindler, C. and Darnell, JE. 1995. Annu Rev Biochem. 64: 621-51. PMID: 7574495
- Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells. | Pallard, C., et al. 1995. J Biol Chem. 270: 15942-5. PMID: 7608147
- Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation. | Yamamoto, K., et al. 1994. Mol Cell Biol. 14: 4342-9. PMID: 8007943
- An interleukin-4-induced transcription factor: IL-4 Stat. | Hou, J., et al. 1994. Science. 265: 1701-6. PMID: 8085155
- Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. | Zhong, Z., et al. 1994. Science. 264: 95-8. PMID: 8140422
- Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. | Darnell, JE., et al. 1994. Science. 264: 1415-21. PMID: 8197455
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Stat1 Antibody (C-136) | sc-464 | 200 µg/ml | $322.00 | |||
Stat1 Antibody (C-136): m-IgGκ BP-HRP Bundle | sc-520415 | 200 µg Ab, 40 µg BP | $361.00 | |||
Stat1 Antibody (C-136) X | sc-464 X | 200 µg/0.1 ml | $322.00 | |||
Stat1 Antibody (C-136) AC | sc-464 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Stat1 Antibody (C-136) HRP | sc-464 HRP | 200 µg/ml | $322.00 | |||
Stat1 Antibody (C-136) FITC | sc-464 FITC | 200 µg/ml | $336.00 | |||
Stat1 Antibody (C-136) PE | sc-464 PE | 200 µg/ml | $349.00 | |||
Stat1 Antibody (C-136) Alexa Fluor® 488 | sc-464 AF488 | 200 µg/ml | $364.00 | |||
Stat1 Antibody (C-136) Alexa Fluor® 546 | sc-464 AF546 | 200 µg/ml | $364.00 | |||
Stat1 Antibody (C-136) Alexa Fluor® 594 | sc-464 AF594 | 200 µg/ml | $364.00 | |||
Stat1 Antibody (C-136) Alexa Fluor® 647 | sc-464 AF647 | 200 µg/ml | $364.00 | |||
Stat1 Antibody (C-136) Alexa Fluor® 680 | sc-464 AF680 | 200 µg/ml | $364.00 | |||
Stat1 Antibody (C-136) Alexa Fluor® 790 | sc-464 AF790 | 200 µg/ml | $364.00 |