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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the C-terminus of HIF-3α of human origin
- recommended for detection of HIF-3α of human origin by WB, IP, IF and ELISA
- blocking peptide, sc-32144 P
- TransCruz reagent for Gel Supershift and ChIP applications, sc-32144 X, 200 µg/0.1 ml
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Informacoes sobre ordens
Produtos Auxiliares Recomendados
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| Especies |
nome do gene |
Identificacao do gene |
Localizacao do cromossomo |
Numero de acesso de isoformas de RNA mensageiro |
Numero de acesso de proteina |
OMIM&trande; Numero |
| Humano |
HIF3A |
64344 |
19q13.32 |
NM_022462, NM_152794, NM_152795 |
Q9Y2N7
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609976 |
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HIF-3α Background Information
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1å, HIF-1∫ (also designated Arnt, EPAS-1 (also designated HIF-2å) and HIF-3å, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1å is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription. Hypoxia-inducible expression of some genes such as Glut-1, p53, p21 or Bcl-2, is HIF-1å dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1å independent. EPAS-1 and HIF-3å have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia. |
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HIF-3α (C-18)
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HIF-3α (C-18): sc-32144. Western blot analysis of human recombinant HIF-3α fusion protein.
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