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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 361-465 mapping within a C-terminal cytoplasmic domain of NK-3R of human origin
- recommended for detection of NK-3R of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
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Informacoes sobre ordens
Produtos Auxiliares Recomendados
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| Especies |
nome do gene |
Identificacao do gene |
Localizacao do cromossomo |
Numero de acesso de isoformas de RNA mensageiro |
Numero de acesso de proteina |
OMIM&trande; Numero |
| Humano |
TACR3 |
6870 |
4q24 |
NM_001059 |
P29371
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162332 |
| camundongo |
Tacr3 |
21338 |
3 G3 |
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P47937
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N/A |
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NK-3R Background Information
Substance P (SP) and neurokinin-A (NK-A) are members of the tachykinins, and they function as modulators of the immune and hematopoietic systems (2). The tachykinins interact with each of three cloned neurokinin (NK) receptors (NK-1R, NK-2R, NK-3R), with SP and NK-A exhibiting binding preferences for NK-1R and NK-2R, respectively (2). NK-4R shares close homology with NK-3R, and both have nearly identical pharmacologicl properties (1). In the normal ileum and colon, NK-1R and NK-2R are localized to smooth muscle cells of the muscularis mucosae and propria and to a few inflammatory cells of the lamina propria (3). NK-1R expression is also found in the muscular wall of submucosal blood vessels, enteric neurons and, to a lesser degree, in surface epithelial cells (3). NK-3R is found in the spinal cord in both lamina X and lamina II (4,5). |
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NK-3R (H-105)
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NK-3R (H-105): sc-28952. Western blot analysis of NK-3R expression in non-transfected 293T: sc-117752 (A), mouse NK-3R transfected 293T: sc-122076 (B) and K-562 (C) whole cell lysates. |
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