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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 376-445 mapping near the C-terminus of GABAA Rρ1 of human origin
- recommended for detection of GABAA Rρ1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
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Informacoes sobre ordens
Produtos Auxiliares Recomendados
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| Especies |
nome do gene |
Identificacao do gene |
Localizacao do cromossomo |
Numero de acesso de isoformas de RNA mensageiro |
Numero de acesso de proteina |
OMIM&trande; Numero |
| Humano |
GABRR1 |
2569 |
6q15 |
NM_002042 |
P24046
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137161 |
| camundongo |
Gabrr1 |
14408 |
4 A5 |
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P56475
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N/A |
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GABAA Rρ1 Background Information
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rå1-6, GABAA R ∫1-3, GABAA R©1-3, GABAA R∂, GABAA Ré, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1å and GABAB R1∫. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action. |
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GABAA Rρ1 (H-70)
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GABAA Rρ1 (H-70): sc-25707. Western blot analysis of GABAA Rρ1 expression in SK-N-SH whole cell lysate.
GABAA Rρ1 (H-70): sc-25707. Immunofluorescence staining of methanol-fixed KNRK cells showing membrane localization.
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