Laminin α-3 Background Information
Laminins are essential and abundant structural non-collagenous glyco-
proteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices (ECMs)) are polymers of laminins with
stabilizing type IV collagen networks, nidogen and several proteoglycans, found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve, and fat cells. Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression, and tissue architecture. Each laminin is a heterotrimer of a, b, and g chain subunits that undergoes cell-secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by integrins, dystroglycan, and cognate laminin receptors. The human laminin a-3 gene maps to chromosome 18q11.2 and encodes the alpha subunit of Laminin-5, which influences cell adhesion, signal transduction and differentiation of keratinocytes.
