CD31/PECAM-1 Antibody (MEC 13.3): sc-18916
- CD31/PECAM-1 Antibody (MEC 13.3) is a rat monoclonal IgG2a, cited in 119 publications, provided at 200 µg/ml
- raised against 129/Sv mouse derived endothelioma cell line tEnd.1
- Anti-CD31/PECAM-1 Antibody (MEC 13.3) is recommended for detection of PECAM-1 of mouse, rat and human origin by WB, IP, IF and FCM
- Anti-CD31/PECAM-1 Antibody (MEC 13.3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also provided azide-free for in vitro and in vivo blocking of adhesion, sc-18916 L, 200 µg/0.1 ml
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD31/PECAM-1 Antibody (MEC 13.3). This work is in progress.
QUICK LINKS
PECAM-1 Antibody (MEC 13.3) is a rat monoclonal IgG2a antibody that detects PECAM-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). PECAM-1, also known as CD31, is a crucial glycoprotein that plays a significant role in mediating cell-cell adhesion, particularly in the vascular system, where PECAM-1 is predominantly expressed on the surfaces of endothelial cells, platelets, and certain leukocytes. PECAM-1 is essential for maintaining vascular integrity and facilitating leukocyte transmigration during inflammatory responses, making PECAM-1 a key player in both immune function and tissue homeostasis. PECAM-1 is also involved in angiogenesis, the process of new blood vessel formation, which is vital for wound healing and tissue repair. Anti-PECAM-1 antibody (MEC 13.3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. By utilizing PECAM-1 monoclonal antibody (MEC 13.3), researchers can gain insights into the dynamics of cell adhesion and migration, which are critical for understanding various physiological and pathological processes, including cancer metastasis and cardiovascular diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD31/PECAM-1 Antibody (MEC 13.3) References:
- PECAM-1-dependent heme oxygenase-1 regulation via an Nrf2-mediated pathway in endothelial cells. | Saragih, H., et al. 2014. Thromb Haemost. 111: 1077-88. PMID: 24500083
- CD31 (PECAM-1) Serves as the Endothelial Cell-Specific Receptor of Clostridium perfringens β-Toxin. | Bruggisser, J., et al. 2020. Cell Host Microbe. 28: 69-78.e6. PMID: 32497498
- Neural cell adhesion molecule (NCAM) as a quantitative marker in synaptic remodeling. | Jørgensen, OS. 1995. Neurochem Res. 20: 533-47. PMID: 7643959
- Cell adhesion receptors and early mammalian heart development: an overview. | Buck, CA., et al. 1993. C R Acad Sci III. 316: 838-59. PMID: 8076214
- Congenital heart disease: three years of surgery. | McCue, CM., et al. 1977. Va Med. 104: 22-9. PMID: 831372
- Vase mini-exon usage by NCAM is not restricted to tumours of neuroectodermal origin. | Patel, K., et al. 1993. Int J Cancer. 54: 772-7. PMID: 8325706
- The Kallmann's syndrome variant (KSV) model of the schizophrenias. | Cowen, MA. and Green, M. 1993. Schizophr Res. 9: 1-10. PMID: 8461265
- Bone marrow micrometastases in a patient with localized Wilms' tumor. | Dominici, C., et al. 1996. Med Pediatr Oncol. 26: 125-8. PMID: 8531850
- Structural requirements for mucosal vascular addressin binding to its lymphocyte receptor alpha 4 beta 7. Common themes among integrin-Ig family interactions. | Briskin, MJ., et al. 1996. J Immunol. 156: 719-26. PMID: 8543825
- Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation. | Berman, ME., et al. 1996. J Immunol. 156: 1515-24. PMID: 8568255
- Developmental control of N-CAM expression by Hox and Pax gene products. | Edelman, GM. and Jones, FS. 1995. Philos Trans R Soc Lond B Biol Sci. 349: 305-12. PMID: 8577842
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD31/PECAM-1 Antibody (MEC 13.3) | sc-18916 | 200 µg/ml | $322.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) L | sc-18916 L | 200 µg/0.1 ml | $322.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) AC | sc-18916 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) HRP | sc-18916 HRP | 200 µg/ml | $322.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) FITC | sc-18916 FITC | 200 µg/ml | $336.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) PE | sc-18916 PE | 200 µg/ml | $349.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) Alexa Fluor® 488 | sc-18916 AF488 | 200 µg/ml | $364.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) Alexa Fluor® 546 | sc-18916 AF546 | 200 µg/ml | $364.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) Alexa Fluor® 594 | sc-18916 AF594 | 200 µg/ml | $364.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) Alexa Fluor® 647 | sc-18916 AF647 | 200 µg/ml | $364.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) Alexa Fluor® 680 | sc-18916 AF680 | 200 µg/ml | $364.00 | |||
CD31/PECAM-1 Antibody (MEC 13.3) Alexa Fluor® 790 | sc-18916 AF790 | 200 µg/ml | $364.00 |