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- mouse monoclonal IgG2b, 200µg/ml
- raised against amino acids 1-156 representing full length CBP20 of human origin
- recommended for detection of CBP20 of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
- TransCruz reagent for Gel Supershift and ChIP applications, sc-137123 X, 200 µg/0.1 ml
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Informacoes sobre ordens
Produtos Auxiliares Recomendados
(clique na sua escolha)
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| Especies |
nome do gene |
Identificacao do gene |
Localizacao do cromossomo |
Numero de acesso de isoformas de RNA mensageiro |
Numero de acesso de proteina |
OMIM&trande; Numero |
| Humano |
NCBP2 |
22916 |
3q29 |
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P52298
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605133 |
| camundongo |
Ncbp2 |
68092 |
16 B2 |
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Q9CQ49
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N/A |
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CBP20 Background Information
In eukaryotes, the majority of mRNAs have an m(7)G cap, which is added cotranscriptionally and plays a critical role in many aspects of mRNA metabolism. The effect of the cap on translation is mediated by the initiation factor eIF-4F, whereas the effect on pre-mRNA splicing involves a nuclear complex (CBC). CBC consists of two cap binding proteins CBP20 and CBP80, which mediate the stimulatory functions of the cap in pre-mRNA splicing, 3' end formation and U snRNA export. The genes CBC1 and CBC2 encode CBP80 and CBP20, respectively. CBP80 comprises three domains, each containing a MIF4G domain. CBP20 has an RNAP fold and associates with the second and third domains of CBP80. CBP also plays a role in nonsense-mediated decay (NMD), which eliminates mRNAs, which prematurely terminate translation. CBP80-bound mRNA undergoes a “pioneer” round of translation before CBP80-
CBP20 are replaced by eIF4E, and Upf2 and Upf3 proteins. |
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CBP20 (B-1)
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CBP20 (B-1): sc-137123. Western blot analysis of CBP20 expression in non-transfected 293: sc-110760 (A), human CBP20 transfected 293: sc-110845 (B) and Ca Ski (C) whole cell lysates and HeLa (D) and SK-BR-3 (E) nuclear extracts. |
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