Myosin Vb (18) Anticorpo: sc-135995

Myosin Vb Background Information
Class V unconventional Myosins, which include Myosin Va and Myosin Vb, are nonfilamentous, Actin-binding enzymes that appear to be expressed ubiquitously. Myosin V proteins are regulated by their heavy chain phosphorylation, which occurs at the C-terminal tail domain. Myosin Vb, also known as MYO5B, is a 1,849 amino acid protein that may be involved in intracellular trafficking. Considered a Rab 8A interacting protein, Myosin Vb regulates intracellular trafficking of GluR from recycling endosomes (REs) to synaptic sites during long-term potentiation. Association with REs triggers rapid spine recruitment of endosomes and local exocytosis in spines. It is suggested that Myosin Vb is required for Insulin-induced Glut4 translocation in muscle cells.