DAP-3 Background Information The death-associated protein 3 (DAP-3), is a nucleotide-binding protein that contains a potential P-loop motif. It is a positive mediator of programmed cell death; overexpressed intact full-length protein is required in order to induce apoptosis. DAP-3 functions downstream of its receptor signaling complex and its death promoting effects depend on caspase activity. It also interacts with the glucocorticoid receptor (GR), where its main interaction domain is the amino-terminal region, which acts in a dominant-negative fashion to protect cells from apoptosis. DAP-3 protein may also play a role in modulating the cytoplasmic GR/HSP 90 complex. It is conserved at the functional, as well as the structural level, and is ubiquitously expressed in highly proliferative epithelial compartments of various tissues. Unlike a number of other proteins, DAP-3 retains its mitochondrial localization during the induction of apoptosis.
DAP-3 (10)
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DAP-3 (10): sc-135876. Western blot analysis of DAP-3 expression in SW-13 whole cell lysate.
DAP-3 (10): sc-135876. Immunofluorescence staining of human endothelial cells showing cytoplasmic localization.
