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- rabbit polyclonal IgG, 100µg/ml
- recommended for detection of UBE2J1 of mouse and human origin by WB, IP, IF, IHC(P) and ELISA
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Informacoes sobre ordens
Produtos Auxiliares Recomendados
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| Especies |
nome do gene |
Identificacao do gene |
Localizacao do cromossomo |
Numero de acesso de isoformas de RNA mensageiro |
Numero de acesso de proteina |
OMIM&trande; Numero |
| Humano |
UBE2J1 |
51465 |
6q15 |
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Q9Y385
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n/a |
| camundongo |
Ube2j1 |
56228 |
4 A5 |
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Q9JJZ4
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N/A |
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UBE2J1 Background Information
Ubiquitination is an important molecular mechanism by which abnormal or short-lived proteins are targeted for degradation by the concerted efforts of at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2J1 (Ubiquitin-conjugating enzyme E2 J1), also known as Ubc6p, CGI-76, NCUBE1, HSPC153 or HSPC205, is a 318 amino acid single-pass type IV membrane protein that belongs to the E2 ubiquitin-conjugating enzyme family and is involved in protein degradation. Localized to the membrane of the endoplasmic reticulum (ER), UBE2J1 catalyzes the attachment of ubiquitin to misfolded membrane proteins, thereby targeting them for proteasomal destruction. This ATP-dependent reaction yields AMP, a diphosphate and a ubiquitin-tagged protein and may be a method of quality control within the ER.
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UBE2J1 (L-23)
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UBE2J1 (L-23): sc-134138. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tissue showing cytoplasmic and membrane localization.
UBE2J1 (L-23): sc-134138. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing cytoplasmic and membrane localization.
UBE2J1 (L-23): sc-134138. Western blot analysis of UBE2J1 expression in Jurkat whole cell lysate.
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