ECHS1 Background Information ECHS1 (enoyl-CoA hydratase 1), also known as SCEH (short chain enoyl-CoA hydratase), is a 290 amino acid protein that localizes to the mitochondrial matrix and belongs to the enoyl-CoA hydratase family. Expressed in muscle, liver and fibroblasts, with low expression in kidney and spleen, ECHS1 exists as a homohexamer that functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. Specifically, ECHS1 catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs, a reaction that is essential for proper lipid metabolism. Human ECHS1 shares 87% homology with its rat counterpart, suggesting a conserved function between species. Multiple isoforms of ECHS1 exist as a result of alternative splicing events. The gene encoding ECHS1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.
ECHS1 (T-24)
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ECHS1 (T-24): sc-133534. Western blot analysis of ECHS1 expression in Jurkat whole cell lysate.
