 |
- rabbit polyclonal IgG, 100µg/ml
- epitope mapping within an extracellular domain of DAGLα of human origin
- recommended for detection of DAGLα isoforms 1-3 of m, r and h origin by WB, IP, IF and ELISA; non cross-reactive with DAGLβ; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-133308 P
|
|
| |
Informacoes sobre ordens
Produtos Auxiliares Recomendados
(clique na sua escolha)
| |
| Especies |
nome do gene |
Identificacao do gene |
Localizacao do cromossomo |
Numero de acesso de isoformas de RNA mensageiro |
Numero de acesso de proteina |
OMIM&trande; Numero |
| Humano |
DAGLA |
747 |
11q12.2 |
|
Q9Y4D2
|
n/a |
| camundongo |
Dagla |
269060 |
19 A |
|
Q6WQJ1
|
N/A |
| |
DAGLα Background Information
Members of the AB hydrolase superfamily have diverse catalytic functions and play a crucial role in the metabolism of lipids. DAGLå (diacylglycerol lipase alpha), also known as NSDDR or C11orf11, is a 1,042 amino acid multi-pass membrane protein that belongs to the AB hydrolase superfamily. Highly expressed in brain and pancreas, DAGLå uses calcium as a cofactor to catalyze the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), a reaction that is required for axonal growth and for retrograde synaptic signaling at mature synapses. DAGLå functions as at optimal pH of 7 and its activity is inhibited by p-hydroxy-mercuri-benzoate and HgCl2. The gene encoding DAGLå maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. |
|
|
DAGLα (N-13)
Clique na imagem para aumenta-la
|
|
DAGLα (N-13): sc-133308. Western blot analysis of DAGLα expression in mouse skeletal muscle tissue extract.
|
|
baixar arquivo
|
|
